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    RGA1 Rga1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854294, updated on 21-May-2012
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    Summary

    Gene symbol
    RGA1
    Gene description
    Rga1p
    Primary source
    SGD:S000005653
    Locus tag
    YOR127W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DBM1; THE1
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    Genomic context

    Location :
    chromosome: XV
    Sequence :
    Chromosome: XV; NC_001147.6 (561170..564193)
    See RGA1 in MapViewer

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Cat5p Neighboring gene Iah1p Neighboring gene Ade2p Neighboring gene Afi1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    2. Tension directly stabilizes reconstituted kinetochore-microtubule attachments. Akiyoshi B, et al. Nature, 2010 Nov 25. PMID 21107429.
    3. A global protein kinase and phosphatase interaction network in yeast. Breitkreutz A, et al. Science, 2010 May 21. PMID 20489023.
    4. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.
    5. Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. Tonikian R, et al. PLoS Biol, 2009 Oct. PMID 19841731.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_014770.1 NP_013330.1 CDC42    BIND  PubMed Cdc42p interacts with Rga1p 
    NP_014770.1 NP_015491.1 RHO1    BIND  PubMed Rho1p interacts with Rga1p 
    NP_014770.1 NP_011668.1 RSR1    BIND  PubMed Rsr1p interacts with Rga1p 
    BioGRID:34522 BioGRID:31400 ACE2    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31107 ACT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36025 AIM44    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35292 ASC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36905 BEM2    BioGRID  PubMed Negative Genetic; Synthetic Lethality; Synthetic Rescue 
    BioGRID:34522 BioGRID:36066 BEM3    BioGRID  PubMed Dosage Rescue; Phenotypic Enhancement 
    BioGRID:34522 BioGRID:35569 BNI1    BioGRID  PubMed Dosage Rescue 
    BioGRID:34522 BioGRID:30980 CDC10    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32859 CDC28    BioGRID  PubMed Biochemical Activity 
    BioGRID:34522 BioGRID:31499 CDC42    BioGRID  PubMed Biochemical Activity; Dosage Rescue; Negative Genetic; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid 
    BioGRID:34522 BioGRID:35540 CLA4    BioGRID  PubMed Dosage Rescue; Negative Genetic; Synthetic Growth Defect; Two-hybrid 
    BioGRID:34522 BioGRID:35907 CLN2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:34522 BioGRID:32813 CMD1    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:34522 BioGRID:31945 CYK3    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36278 DBF20    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35002 DSN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34522 BioGRID:33186 DUO1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:34085 ELM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31902 ENT1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:34522 BioGRID:35743 EOS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31604 FKS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35487 GAS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32362 GIC2    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:36728 GIM4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34522 BioGRID:32559 GIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31384 HOG1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:33086 HUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36837 IES5    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:33874 ILM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:33969 KKQ8    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35517 LEM3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:34522 BioGRID:36125 LGE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34522 BioGRID:33144 MLC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34522 BioGRID:31460 MMR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32296 MNN10    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31731 MTW1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:34711 MYO2    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34522 BioGRID:32213 NBP2    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35649 NPR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:33320 PAC10    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34522 BioGRID:33628 PBS2    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:34522 BioGRID:33087 PMR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32048 PTC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32438 RGA2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34522 BioGRID:36338 RHO1    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:31315 RIC1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34522 BioGRID:31114 RIM15    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31631 ROM2    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36755 RPN3    BioGRID  PubMed PCA 
    BioGRID:34522 BioGRID:34450 RSB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34522 BioGRID:33400 RSR1    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:36863 SHO1    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:31833 SHR3    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31885 SHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32692 SLA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:33481 SMI1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:36419 STE20    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34522 BioGRID:34607 STE4    BioGRID  PubMed Phenotypic Enhancement; Synthetic Rescue 
    BioGRID:34522 BioGRID:31755 SWC3    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:33575 SWE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32200 SWI5    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:35325 SWP1    BioGRID  PubMed Positive Genetic 
    BioGRID:34522 BioGRID:33348 VMA21    BioGRID  PubMed Positive Genetic 
    BioGRID:34522 BioGRID:35046 VPS9    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:32240 YDR186C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34522 BioGRID:36382 YHL042W    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:33577 YJL185C    BioGRID  PubMed Two-hybrid 
    BioGRID:34522 BioGRID:33808 YJR054W    BioGRID  PubMed Negative Genetic 
    BioGRID:34522 BioGRID:31469 YKE2    BioGRID  PubMed Synthetic Growth Defect 
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    General gene information

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Rho GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Rho GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Rho GTPase activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    budding cell apical bud growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    budding cell isotropic bud growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    invasive growth in response to glucose limitation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    pheromone-dependent signal transduction involved in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    pseudohyphal growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    response to pheromone IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular bud neck split septin rings IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Rga1p
    NP_014770.1
    • GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6

      Range
      561170..564193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183546.1 → NP_014770.1  Rga1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P39083
      Conserved Domains (5) summary
      cd00159
      Location:805 – 1001
      Blast Score: 338
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      TIGR02168
      Location:575 – 674
      Blast Score: 105
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09394
      Location:13 – 67
      Blast Score: 305
      LIM1_Rga; The first LIM domain of Rga GTPase-Activating Proteins
      cd09395
      Location:70 – 123
      Blast Score: 268
      LIM2_Rga; The second LIM domain of Rga GTPase-Activating Proteins
      smart00324
      Location:803 – 1002
      Blast Score: 408
      RhoGAP; GTPase-activator protein for Rho-like GTPases
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006948.2 DAA10901.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39083.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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