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HIR2 Hir2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 854203, updated on 12-Jul-2016
Gene symbol
HIR2
Gene description
Hir2p
Primary source
SGD:S000005564
Locus tag
YOR038C
Gene type
protein coding
RNA name
Hir2p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SPT1
See HIR2 in Map Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (402761..405388, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene hydroxyacylglutathione hydrolase GLO4

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to nucleosome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA replication-independent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
covalent chromatin modification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription elongation from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
HIR complex IDA
Inferred from Direct Assay
more info
PubMed 
HIR complex IPI
Inferred from Physical Interaction
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Hir2p
NP_014681.1
  • Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    402761..405388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183457.1NP_014681.1  Hir2p [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_014681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32480
    Conserved Domains (3) summary
    COG2319
    Location:83367
    WD40; WD40 repeat [General function prediction only]
    pfam07569
    Location:580824
    Hira; TUP1-like enhancer of split
    cl02567
    Location:172350
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...