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    COQ10 Coq10p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854154, updated on 8-Jan-2012
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    Summary

    Gene symbol
    COQ10
    Gene description
    Coq10p
    Primary source
    SGD:S000005368
    Locus tag
    YOL008W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XV; NC_001147.6 (310312..310935)
    See COQ10 in MapViewer

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rcl1p Neighboring gene Mdm12p Neighboring gene Csi2p Neighboring gene Top1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475.
    3. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Echtenkamp FJ, et al. Mol Cell, 2011 Jul 22. PMID 21777812.
    4. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Reid RJ, et al. Genome Res, 2011 Mar. PMID 21173034.
    5. Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration. Zampol MA, et al. Biochem Biophys Res Commun, 2010 Nov 5. PMID 20933507.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that wild-type and coq10 mitochondria accumulate similar amounts of Q(6) semiquinone.
      Title: Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A.
    2. These results indicate that Coq10p binds Q6 in vivo and that this property is essential for a normal functioning of the electron transport chain.
      Title: Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration.
    3. Coq10p is a Q6-binding protein and in the coq10 mutant Q6 it is not able to act as an electron carrier, possibly because of improper localization
      Title: The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34396 BioGRID:33761 APL1    BioGRID  PubMed Positive Genetic 
    BioGRID:34396 BioGRID:35524 ATP11    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34129 AUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34520 CAT5    BioGRID  PubMed Dosage Rescue 
    BioGRID:34396 BioGRID:31825 CDC13    BioGRID  PubMed Synthetic Rescue 
    BioGRID:34396 BioGRID:33227 CKB1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:33419 CLC1    BioGRID  PubMed Positive Genetic 
    BioGRID:34396 BioGRID:36907 COG3    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35867 COQ2    BioGRID  PubMed Dosage Rescue 
    BioGRID:34396 BioGRID:33132 COQ8    BioGRID  PubMed Dosage Rescue; Phenotypic Suppression 
    BioGRID:34396 BioGRID:31360 CSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:33360 DAM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34131 DID4    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:33952 DOA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34469 GYP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:32479 HKR1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34263 HPF1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36528 HXT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:32368 IPK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34543 MDM32    BioGRID  PubMed Positive Genetic 
    BioGRID:34396 BioGRID:36836 MET6    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:31245 MMM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35077 MSC1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35959 NEW1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34092 NFU1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:31838 NHP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:34396 BioGRID:34745 PDE2    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36024 PET20    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36035 PPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:33096 RCK1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35250 RCO1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35547 RFC3    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:32047 RPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34018 SBA1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34396 BioGRID:31296 SDO1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36096 SEC16    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36368 SGE1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:31885 SHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35603 SIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:32923 SLX1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:32895 TAF5    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34685 TIM18    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34398 TOP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:34396 BioGRID:31463 UPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:35831 VPS27    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:33687 YJL068C    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34206 YKR075C    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:34235 YKR104W    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:31421 YLR152C    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36072 YPL109C    BioGRID  PubMed Negative Genetic 
    BioGRID:34396 BioGRID:36589 YSP1    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ubiquinone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Coq10p
    NP_014635.1
    • Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6

      Range
      310312..310935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183262.1 → NP_014635.1  Coq10p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q08058
      Conserved Domains (1) summary
      cd07813
      Location:46 – 192
      Blast Score: 328
      COQ10p_like; Coenzyme Q-binding protein COQ10p and similar proteins
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006948.2 DAA10775.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q08058.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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