SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 [Homo sapiens] - Gene

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Summary

Official Symbol: SLC22A16provided by HGNC
Official Full Name: solute carrier family 22 (organic cation/carnitine transporter), member 16provided by HGNC
Primary source: HGNC:20302
Locus tag: RP1-261K5.1
See related: Ensembl:ENSG00000004809; HPRD:12202; MIM:608276; Vega:OTTHUMG00000016171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT2; OAT6; OCT6; OKB1; FLIPT2; dJ261K5.1
Summary: This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

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Genomic context

Location :: 6q22.1; 6q21-q22.1

Sequence :: Chromosome: 6; NC_000006.11 (110745906..110797844, complement)

See SLC22A16 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

cytotoxic assays, stable transfectants of leukemic Jurkat cells overexpressing SLC22A16 cells became significantly more sensitive to doxorubicin
Title: Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.
Observational study of gene-disease association. (HuGE Navigator)
Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
Variant alleles in the ABCB1, SLC22A16 and CYP2B6 genes are associated with response to AC therapy in the treatment of breast cancer.
Title: Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.
that hCT2 can mediate bleomycin-A5 and polyamine uptake, and that the rate of bleomycin-A5 accumulation may account for the differential response to the drug in patients.
Title: The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients.
Exploratory study suggests that the c.146A>G variation could contribute to variations in the pharmacokinetics of doxorubicin and doxorubicinol in Asian breast cancer patients.
Title: Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients.
SLC22A16 was abundantly expressed in clear-cell adenocarcinomaof the ovary.
Title: Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.
Flipts might have a role in carnitine transport, particularly in brain
Title: Novel human cDNAs homologous to Drosophila Orct and mammalian carnitine transporters.
may be possible to use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens
Title: Expression of organic cation transporter SLC22A16 in human endometria.

Submit: New GeneRIF Correction See all (12)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Function	Evidence Code	Pubs
amine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
carnitine transporter activity	IDA Inferred from Direct Assay more info	PubMed
organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acid secretion	IDA Inferred from Direct Assay more info	PubMed
carnitine transport	IDA Inferred from Direct Assay more info	PubMed
cell differentiation	IEA Inferred from Electronic Annotation more info
ion transport	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
organic cation transport	IDA Inferred from Direct Assay more info	PubMed
single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
spermatogenesis	IEA Inferred from Electronic Annotation more info
transmembrane transport	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IC Inferred by Curator more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: solute carrier family 22 member 16

Names: solute carrier family 22 member 16; flipt 2; WUGSC:RG331P03.1; carnitine transporter 2; organic cation transporter 6; fly-like putative transporter 2; organic cation transporter OKB1; organic cation/carnitine transporter 6; fly-like putative organic ion transporter 2; solute carrier family 22 (organic cation transporter), member 16

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033125.3 → NP_149116.2 solute carrier family 22 member 16

Status: VALIDATED

Source sequence(s)

AC002464, AI632467, BC047565

Consensus CDS

CCDS5084.1

UniProtKB/Swiss-Prot

Q86VW1

Related

ENSP00000357915, OTTHUMP00000017785, ENST00000368919, OTTHUMT00000043428

Conserved Domains (2) summary

cd06174
Location:128 – 288
Blast Score: 182

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:14 – 535
Blast Score: 922

2A0119; cation transport protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

110745906..110797844, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

108312828..108364722, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC002464.1	AAB67044.1
genomic	AL050350.14	CAI42512.1
		CAI42514.1
genomic	CH471051.2	EAW48313.1
		EAW48314.1
		EAW48315.1
mRNA	AB055798.1	BAC23062.1
mRNA	AF268892.1	AAK58593.1
mRNA	AI632467.1	None
mRNA	AK057306.1	BAB71419.1
mRNA	AK304546.1	BAG65342.1
mRNA	AY145502.1	AAN52928.1
mRNA	BC012014.1	AAH12014.1
mRNA	BC037247.1	None
mRNA	BC047565.1	AAH47565.1
other-genetic	JF432782.1	ADZ15999.1