NKD2 naked cuticle homolog 2 (Drosophila) [Homo sapiens] - Gene

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Summary

Official Symbol: NKD2provided by HGNC
Official Full Name: naked cuticle homolog 2 (Drosophila)provided by HGNC
Primary source: HGNC:17046
See related: Ensembl:ENSG00000145506; HPRD:08483; MIM:607852; Vega:OTTHUMG00000090348
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Naked2
Summary: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

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Genomic context

Location :: 5p15.3

Sequence :: Chromosome: 5; NC_000005.9 (1009168..1038925)

See NKD2 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation.
Title: Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane.
identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
Title: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.
Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells.
Title: Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.
NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.
Title: Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NKD2	P01135	TGFA	HPRD	PubMed
BioGRID:124517	BioGRID:107305	CAV1	BioGRID	PubMed	Co-fractionation
BioGRID:124517	BioGRID:107434	CDH1	BioGRID	PubMed	Co-fractionation
BioGRID:124517	BioGRID:108188	DVL1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:124517	BioGRID:122133	RNF25	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124517	BioGRID:112897	TGFA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124517	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
exocytosis	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic membrane-bounded vesicle	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein naked cuticle homolog 2

Names: protein naked cuticle homolog 2; hNkd2; naked-2; naked cuticle-2; Dvl-binding protein NKD2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033120.2 → NP_149111.1 protein naked cuticle homolog 2

Status: PROVISIONAL

Source sequence(s)

AB062887

Consensus CDS

CCDS3859.1

UniProtKB/Swiss-Prot

Q969F2

Related

ENSP00000296849, OTTHUMP00000115406, ENST00000296849, OTTHUMT00000206720

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

1009168..1038925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

993647..1021593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC116351.2 (34979..64736)	None
genomic	CH471102.2	EAX08182.1
		EAX08183.1
		EAX08184.1
mRNA	AB062887.1	BAB70501.1
mRNA	AF358137.1	AAK57486.1
mRNA	BC004940.1	AAH04940.1
mRNA	BC012176.1	AAH12176.1