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DUF1 Duf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854066, updated on 13-Apr-2024

Summary

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Gene symbol
DUF1
Gene description
Duf1p
Primary source
SGD:S000005447
Locus tag
YOL087C
See related
AllianceGenome:SGD:S000005447
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein deubiquitination. Located in cytoplasm. Orthologous to human WDR48 (WD repeat domain 48). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (155287..158637, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hal9p Neighboring gene protein disulfide isomerase MPD2 Neighboring gene Mhf1p Neighboring gene alcohol dehydrogenase ADH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemotyping of yeast mutants using robotics. Rieger KJ, et al. Yeast, 1999 Jul. PMID 10407277
  2. Construction of PCR-ligated long flanking homology cassettes for use in the functional analysis of six unknown open reading frames from the left and right arms of Saccharomyces cerevisiae chromosome XV. Pearson BM, et al. Yeast, 1998 Mar 15. PMID 9559547
  3. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. Kanga S, et al. PLoS One, 2012. PMID 22723847, Free PMC Article
  4. WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Pashkova N, et al. Mol Cell, 2010 Nov 12. PMID 21070969, Free PMC Article
  5. Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins. Konduri PC, et al. Cells, 2020 Mar 22. PMID 32235736, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Duf1p
NP_014554.1
  • Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    155287..158637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183341.1 → NP_014554.1  TPA: Duf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014554.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Y1, Q99247
    UniProtKB/TrEMBL
    A0A8H4BWQ8, N1NWC4
    Conserved Domains (3) summary
    sd00039
    Location:165 → 207
    7WD40; WD40 repeat [structural motif]
    cd17041
    Location:1018 → 1098
    Ubl_WDR48; Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins
    cl29593
    Location:10 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99247.1

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