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Shc1 SHC (Src homology 2 domain containing) transforming protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85385, updated on 26-May-2016
Official Symbol
Shc1provided by RGD
Official Full Name
SHC (Src homology 2 domain containing) transforming protein 1provided by RGD
Primary source
RGD:620446
See related
Ensembl:ENSRNOG00000020657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
P66shc
Summary
mouse homolog interacts with growth factor receptors; involved in transformation and differentiation in a Ras-dependent fashion [RGD, Feb 2006]
Orthologs
Location:
2q34
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188745503..188757066)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (208159786..208171348)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene lens epithelial protein Neighboring gene CDC28 protein kinase regulatory subunit 1B Neighboring gene pygopus family PHD finger 2 Neighboring gene pre-B-cell leukemia homeobox interacting protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor binding ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
neurotrophin TRKA receptor binding IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton reorganization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
aging IPI
Inferred from Physical Interaction
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
single organismal cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
single organismal cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Shc-EGFR complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
SHC-transforming protein 1
Names
SH2 domain protein C1
SHC (Src homology 2 domain-containing) transforming protein 1
src homology 2 domain-containing transforming protein C1
src homology 2 domain-containing-transforming protein C1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164060.1NP_001157532.1  SHC-transforming protein 1 isoform a

    See identical proteins and their annotated locations for NP_001157532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC098750
    UniProtKB/TrEMBL
    G3V8S2
    Related
    ENSRNOP00000028038, ENSRNOT00000028038
    Conserved Domains (2) summary
    cd09925
    Location:476578
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:146317
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
  2. NM_053517.2NP_445969.2  SHC-transforming protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC098750, BC088298, CB813924
    UniProtKB/Swiss-Prot
    Q5M824
    UniProtKB/TrEMBL
    F1LN14
    Related
    ENSRNOP00000053490, ENSRNOT00000056652
    Conserved Domains (2) summary
    cd09925
    Location:366468
    SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
    cd01209
    Location:36207
    PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    188745503..188757066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    168778680..168790241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)