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    CMC1 Cmc1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853721, updated on 4-Feb-2012
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    Summary

    Gene symbol
    CMC1
    Gene description
    Cmc1p
    Primary source
    SGD:S000001620
    Locus tag
    YKL137W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: XI; NC_001143.9 (185957..186292)
    See CMC1 in MapViewer

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Hsk3p Neighboring gene Mrpl31p Neighboring gene Apl2p Neighboring gene Oct1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Scherrer T, et al. Genome Biol, 2011. PMID 21232131.
    2. The conserved mitochondrial twin Cx9C protein Cmc2 Is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Horn D, et al. J Biol Chem, 2010 May 14. PMID 20220131.
    3. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.
    4. Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. Batisse J, et al. J Biol Chem, 2009 Dec 11. PMID 19840948.
    5. Systematic analysis of the twin cx(9)c protein family. Longen S, et al. J Mol Biol, 2009 Oct 23. PMID 19703468.

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results suggest that Cmc1p could play a direct or indirect role in copper trafficking and distribution to COX and Sod1p.
      Title: Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:34000 BioGRID:31107 ACT1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32249 CBS2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32639 CMC2    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:34000 BioGRID:31484 CPR6    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:31753 DEP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:34131 DID4    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:35499 FET4    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34000 BioGRID:36877 GLC7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:34000 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32543 IZH1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:33495 LSC2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:33632 LSM1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:36836 MET6    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32447 MUS81    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:34000 BioGRID:35959 NEW1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:34745 PDE2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:35726 PHO23    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32019 PRM7    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:35659 PSD1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:36819 PTP3    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:35620 RAP1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:31680 RPN13    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:31553 RPS30A    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32047 RPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:33408 RTS3    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:36739 SEC3    BioGRID  PubMed Positive Genetic 
    BioGRID:34000 BioGRID:35603 SIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32692 SLA1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:31866 SOR2    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32627 SSA3    BioGRID  PubMed Positive Genetic 
    BioGRID:34000 BioGRID:31792 SWD1    BioGRID  PubMed Positive Genetic 
    BioGRID:34000 BioGRID:35200 TAP42    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32162 TMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:34446 TOM6    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:34000 BioGRID:32039 TSC13    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:34971 VID28    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32841 YBR141C    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:32933 YBR238C    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:33876 YJR120W    BioGRID  PubMed Negative Genetic 
    BioGRID:34000 BioGRID:34310 YOL092W    BioGRID  PubMed Negative Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    mitochondrial respiratory chain complex IV assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extrinsic to mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Cmc1p
    NP_012785.2
    • Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9

      Range
      185957..186292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179703.1 → NP_012785.2  Cmc1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36064
      Conserved Domains (1) summary
      pfam08583
      Location:30 – 98
      Blast Score: 169
      Cmc1; Cytochrome c oxidase biogenesis protein Cmc1 like
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006944.2 DAA09026.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P36064.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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