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DOA1 Doa1p [ Saccharomyces cerevisiae S288c ]

Gene ID: 853667, updated on 8-Mar-2015
Gene symbol
DOA1
Gene description
Doa1p
Primary source
SGD:S000001696
Locus tag
YKL213C
Gene type
protein coding
RNA name
Doa1p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
UFD3; ZZZ4
See DOA1 in MapViewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (31960..34107, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Oxp1p Neighboring gene Yra2p Neighboring gene phosphatidylinositol-3-phosphatase SAC1 Neighboring gene bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Doa1p
NP_012709.1
  • WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    31960..34107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179778.1NP_012709.1  Doa1p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_012709.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36037
    Conserved Domains (4) summary
    COG2319
    Location:25310
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:5288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08324
    Location:465714
    PUL; PUL domain
    pfam09070
    Location:331445
    PFU; PFU (PLAA family ubiquitin binding)