CAMK1 calcium/calmodulin-dependent protein kinase I [Homo sapiens] - Gene

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Summary

Official Symbol: CAMK1provided by HGNC
Official Full Name: calcium/calmodulin-dependent protein kinase Iprovided by HGNC
Primary source: HGNC:1459
See related: Ensembl:ENSG00000134072; HPRD:05412; MIM:604998; Vega:OTTHUMG00000128419
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAMKI; MGC120317; MGC120318
Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 3p25.3

Sequence :: Chromosome: 3; NC_000003.11 (9799029..9811668, complement)

See CAMK1 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CaMKI was significantly upregulated in adrenal adenomas.
Title: Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, have roles in memory and general cognitive abilities
Title: Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of 182 candidate genes in anorexia nervosa.
Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.
Title: Dioxin-mediated up-regulation of aryl hydrocarbon receptor target genes is dependent on the calcium/calmodulin/CaMKIalpha pathway.
Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation
Title: Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation.
we cloned a novel calmodulin-kinase (CaM-KIdelta) from HeLa cells and characterized its activation mechanism. CaM-KIdelta exhibits Ca(2+)/CaM-dependent activity that is enhanced in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha
Title: Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.
CaMKI is involved in angiotensin II and K(+) stimulation of CYP11B2 transcription and the capacity of the adrenal to produce aldosterone
Title: Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase.
calcium/calmodulin-dependent protein kinase I regulates of cyclin D1/Cdk4 complexes
Title: Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including CAMK1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14012	P18846	ATF1	HPRD	PubMed
Q14012	Calmodulin 1	CALM1	HPRD	PubMed
Q14012	Q14012	CAMK1	HPRD	PubMed
Q14012	Q8N5S9	CAMKK1	HPRD	PubMed
Q14012	Q96RR4	CAMKK2	HPRD	PubMed
Q14012	O43432	EIF4G3	HPRD	PubMed
Q14012	P04406	GAPDH	HPRD	PubMed
Q14012	Q9UQL6	HDAC5	HPRD	PubMed
Q14012	P29475	NOS1	HPRD	PubMed
Q14012	P17600	SYN1	HPRD	PubMed
BioGRID:114106	BioGRID:115889	CAMKK2	BioGRID	PubMed	Biochemical Activity
BioGRID:114106	BioGRID:114093	GCM1	BioGRID	PubMed	Biochemical Activity
BioGRID:114106	BioGRID:115106	HDAC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114106	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114106	BioGRID:115083	HDAC9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114106	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
calmodulin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info
nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: calcium/calmodulin-dependent protein kinase type 1

Names: calcium/calmodulin-dependent protein kinase type 1; caM-KI; caMKI-alpha; caM kinase I alpha

NP_003647.1

EC 2.7.11.17

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003656.4 → NP_003647.1 calcium/calmodulin-dependent protein kinase type 1

Status: REVIEWED

Source sequence(s)

AA724193, BC106754, DN990042

Consensus CDS

CCDS2582.1

UniProtKB/TrEMBL

B0YIY3

UniProtKB/Swiss-Prot

Q14012

Related

ENSP00000256460, OTTHUMP00000158527, ENST00000256460, OTTHUMT00000250206

Conserved Domains (2) summary

cd05123
Location:26 – 275
Blast Score: 655

STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases

smart00220
Location:20 – 276
Blast Score: 900

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

9799029..9811668, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

9735376..9748016, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC022382.4 (65553..78183)	None
genomic	CH471055.1	EAW63989.1
		EAW63990.1
		EAW63991.1
		EAW63992.1
		EAW63993.1
genomic	EF444963.1	ACA05961.1
mRNA	AA724193.1	None
mRNA	AB451277.1	BAG70091.1
mRNA	AB451407.1	BAG70221.1
mRNA	AK314917.1	BAG37428.1
mRNA	BC106754.2	AAI06755.1
mRNA	BC106755.2	AAI06756.1
mRNA	BI546222.1	None
mRNA	DN990042.1	None
mRNA	L41816.1	AAA99458.1
other-genetic	EU832761.1	ACE87772.1
other-genetic	GQ129304.1	ACT64438.1