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    JSN1 Jsn1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853553, updated on 21-Jan-2012
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    Summary

    Gene symbol
    JSN1
    Gene description
    Jsn1p
    Primary source
    SGD:S000003851
    Locus tag
    YJR091C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PUF1
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    Genomic context

    Sequence :
    Chromosome: X; NC_001142.9 (595061..598336, complement)
    See JSN1 in MapViewer

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Bir1p Neighboring gene Grr1p Neighboring gene Bud4p Neighboring gene Fip1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Interactomic study on interaction between lipid droplets and mitochondria. Pu J, et al. Protein Cell, 2011 Jun. PMID 21748599.
    3. Divergent RNA binding specificity of yeast Puf2p. Yosefzon Y, et al. RNA, 2011 Aug. PMID 21685478.
    4. Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Cridge AG, et al. Nucleic Acids Res, 2010 Dec. PMID 20705650.
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336.

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results identify the first mRNA targets of Puf1p-mediated decay.
      Title: Puf1p acts in combination with other yeast Puf proteins to control mRNA stability.
    2. Thus, Jsn1p has physical interactions with mitochondria-associated Arp2/3 complex and contributes to physical and functional association of the Arp2/3 complex with mitochondria.
      Title: A role for Jsn1p in recruiting the Arp2/3 complex to mitochondria in budding yeast.
    3. Ccr4p catalyzes PUF protein-mediated deadenylation using a Pop2p bridge to recruit a multifunctional Pop2p complex to the mRNA
      Title: PUF protein-mediated deadenylation is catalyzed by Ccr4p.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:33845 BioGRID:33800 ANB1    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:31630 ARC18    BioGRID  PubMed Co-localization; Negative Genetic 
    BioGRID:33845 BioGRID:31651 ART10    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:31194 CDC26    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:32859 CDC28    BioGRID  PubMed Biochemical Activity 
    BioGRID:33845 BioGRID:33405 CHO2    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:36489 CPR2    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:35419 CUS1    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:34131 DID4    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:33919 EAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33845 BioGRID:35161 ERG6    BioGRID  PubMed PCA 
    BioGRID:33845 BioGRID:34704 FAA1    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:34969 FAF1    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:34927 FIS1    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:36728 GIM4    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:35049 GIM5    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:33469 GPI1    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:31462 HCR1    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33845 BioGRID:31211 HXK1    BioGRID  PubMed Protein-RNA 
    BioGRID:33845 BioGRID:34321 IRA2    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:33845 JSN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:33845 BioGRID:33993 LTV1    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:34226 MLP1    BioGRID  PubMed Phenotypic Suppression; Positive Genetic 
    BioGRID:33845 BioGRID:36811 MOT2    BioGRID  PubMed Negative Genetic; PCA 
    BioGRID:33845 BioGRID:33076 MPT5    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:33845 BioGRID:34285 PAP2    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:34178 PET10    BioGRID  PubMed PCA 
    BioGRID:33845 BioGRID:36024 PET20    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:36713 PMP2    BioGRID  PubMed Affinity Capture-RNA; Two-hybrid 
    BioGRID:33845 BioGRID:34021 RAD27    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:31999 RAD59    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:33845 BioGRID:34654 RBL2    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:31334 REX2    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:31911 RPC53    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:31914 RPN5    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:31921 RPO21    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:34419 RTS1    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:32449 RVS167    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:32450 SAC7    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:35441 SAP30    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:32041 SLX5    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:34168 SPC34    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:34959 SSM4    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:35154 TAF11    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:34190 TIF1    BioGRID  PubMed Protein-RNA 
    BioGRID:33845 BioGRID:35447 TMA23    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:31109 TUB2    BioGRID  PubMed Dosage Rescue 
    BioGRID:33845 BioGRID:34683 UAF30    BioGRID  PubMed Positive Genetic 
    BioGRID:33845 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33845 BioGRID:35242 UBX4    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:33261 UGA1    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:31679 URA4    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:36717 VAC8    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:36457 VMA16    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:34133 VPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:33845 BioGRID:33649 YJL107C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33845 BioGRID:31427 YLR156W    BioGRID  PubMed Two-hybrid 
    BioGRID:33845 BioGRID:35873 YNR048W    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular protein complex localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    external side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Jsn1p
    NP_012624.1
    • Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9

      Range
      595061..598336, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181748.1 → NP_012624.1  Jsn1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P47135
      Conserved Domains (3) summary
      COG5099
      Location:58 – 914
      Blast Score: 1242
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:362 – 412
      Blast Score: 118
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      cl02427
      Location:595 – 907
      Blast Score: 252
      Pumilio; Pumilio-family RNA binding domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006943.2 DAA08875.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P47135.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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