CBX4 chromobox homolog 4 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CBX4provided by HGNC
Official Full Name: chromobox homolog 4provided by HGNC
Primary source: HGNC:1554
See related: Ensembl:ENSG00000141582; HPRD:04357; MIM:603079; Vega:OTTHUMG00000150415
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PC2; NBP16

Help top of page

Genomic context

Location :: 17q25.3

Sequence :: Chromosome: 17; NC_000017.10 (77806955..77813213, complement)

See CBX4 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High Polycomb repressive complex protein is associated with mesothelioma.
Title: Polycomb repressor complex-2 is a novel target for mesothelioma therapy.
Pc2, methylation controls the protein's interaction with two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive subnuclear localization of methylated and unmethylated Pc2 in Polycomb bodies and interchromatin granules, respectively.
Title: ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs.
plays role in regulation of epidermal stem cell proliferation and senescence
Title: Regulation of human epidermal stem cell proliferation and senescence requires polycomb- dependent and -independent functions of Cbx4.
Data show that PRC2 can integrate information provided by pre-existing histone modifications to accurately tune its enzymatic activity within a particular chromatin context.
Title: Histone methylation by PRC2 is inhibited by active chromatin marks.
the hPc2-induced SUMOylation of alpha-synuclein could function as a cytoprotector by increasing alpha-synuclein aggregate formation within fibroblast cells.
Title: Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation.
14-3-3 protein binding to chromobox homolog 4 (CBX4) appears to modulate the interaction between CBX4 and the BMI1/PCGF components of polycomb recessive complex 1, but has no effect on CBX4-RING1/RNF2 interaction
Title: Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells.
A phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2.
Title: The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
Huntingtin is a novel stimulator of polycomb repressive complex 2.
Title: Huntingtin facilitates polycomb repressive complex 2.
Results show that DNA methyltransferase 3B enhances polycomb protein 2-mediated transcriptional repression of FGFR3, and suggest that DNMT3B is a co-repressor of hPc2 in inducing transcriptional repression independent of DNA methylation.
Title: DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription.
The Endoplasmic reticulum-associated degradation (ERAD) machinery may thus be important for autosomal dominant polycystic kidney disease pathogenesis because the regulation of PC2 expression by the ERAD pathway is altered by mutations in PC2.
Title: Polycystin-2 is regulated by endoplasmic reticulum-associated degradation.

Submit: New GeneRIF Correction See all (14)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
AAB80718.1	AAB80718.1	CBX4	BIND	PubMed	Pc2 interacts with Pc2.
AAB80718.1	NP_001319.1	CTBP1	BIND	PubMed	Pc2 interacts with CtBP1.
AAB80718.1	AAP36016.1	RING1	BIND	PubMed	RING1 interacts with HPC2.
AAB80718.1	NP_003343.1	SUMO1	BIND	PubMed	Pc2 interacts with SUMO1.
AAB80718.1	NP_003336.1	UBE2I	BIND	PubMed	Ubc9 interacts with Pc2.
NP_003646.2	NP_001440.2	FHL1	BIND	PubMed	KyoT1 interacts with HPC2. This interaction was modeled on a demonstrated interaction between KyoT1 from an unspecified species and human HPC2.
NP_003646.2	NP_004626.1	MAPKAPK3	BIND	PubMed	3pK interacts with HPc2.
NP_003646.2	NP_004417.1	PHC1	BIND	PubMed	HPH1 interacts with HPc2.
NP_003646.2	NP_009143.1	RNF2	BIND	PubMed	Rnf2 interacts with HPc2.
O00257	Q13363	CTBP1	HPRD	PubMed
O00257	P56545	CTBP2	HPRD	PubMed
O00257	Q13642	FHL1	HPRD	PubMed
O00257	MED9	MED9	HPRD	PubMed
O00257	P06400	RB1	HPRD	PubMed
O00257	Q06587	RING1	HPRD	PubMed
O00257	Q99496	RNF2	HPRD	PubMed
O00257	P12757	SKIL	HPRD	PubMed
O00257	P63279	UBE2I	HPRD	PubMed
BioGRID:114105	BioGRID:107116	BMI1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114105	BioGRID:198359	Bmi1	BioGRID	PubMed	Affinity Capture-MS; Co-purification
BioGRID:114105	BioGRID:107869	CTBP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:114105	BioGRID:107870	CTBP2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114105	BioGRID:198535	Cbx2	BioGRID	PubMed	Affinity Capture-MS; Co-purification
BioGRID:114105	BioGRID:108125	DNMT3A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114105	BioGRID:246582	Grm4	BioGRID	PubMed	Reconstituted Complex
BioGRID:114105	BioGRID:246584	Grm6	BioGRID	PubMed	Reconstituted Complex
BioGRID:114105	BioGRID:249569	Grm7	BioGRID	PubMed	Reconstituted Complex
BioGRID:114105	BioGRID:248875	Grm8	BioGRID	PubMed	Reconstituted Complex
BioGRID:114105	BioGRID:113895	HIST3H3	BioGRID	PubMed	Biochemical Activity
BioGRID:114105	BioGRID:115984	KDM5B	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114105	BioGRID:110322	MBD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114105	BioGRID:110443	MLL	BioGRID	PubMed	Reconstituted Complex
BioGRID:114105	BioGRID:113497	PCGF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114105	BioGRID:108233	PHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114105	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Enhancement
BioGRID:114105	BioGRID:111947	RING1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114105	BioGRID:111972	RNF2	BioGRID	PubMed	Two-hybrid
BioGRID:114105	BioGRID:112211	SATB1	BioGRID	PubMed	Two-hybrid
BioGRID:114105	BioGRID:112506	SNCA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114105	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114105	BioGRID:112706	SUV39H1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:114105	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114105	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
chromatin binding	IEA Inferred from Electronic Annotation more info
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
methylated histone residue binding	IEA Inferred from Electronic Annotation more info
phosphoprotein binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
single-stranded RNA binding	IEA Inferred from Electronic Annotation more info
transcription corepressor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
anti-apoptosis	TAS Traceable Author Statement more info	PubMed
chromatin modification	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
PcG protein complex	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: E3 SUMO-protein ligase CBX4

Names: E3 SUMO-protein ligase CBX4; Pc class 2 homolog; polycomb 2 homolog; NS5ATP1-binding protein 16; chromobox protein homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila)

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003655.2 → NP_003646.2 E3 SUMO-protein ligase CBX4

Status: VALIDATED

Source sequence(s)

AF013956, AI796748, BC014967, BG029608, BQ225831

Consensus CDS

CCDS32758.1

UniProtKB/Swiss-Prot

O00257

Related

ENSP00000269397, OTTHUMP00000197308, ENST00000269397, OTTHUMT00000318007

Conserved Domains (1) summary

cd00024
Location:10 – 60
Blast Score: 152

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

77806955..77813213, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

73247786..73258221, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC100791.15 (71378..77636)	None
genomic	CH471099.1	EAW89572.1
		EAW89573.1
mRNA	AF013956.1	AAB80718.1
mRNA	AI796748.1	None
mRNA	AY390430.1	AAQ97596.1
mRNA	BC014967.1	AAH14967.1
mRNA	BG029608.1	None
mRNA	BQ225831.1	None
mRNA	EU439707.1	ACA49234.1
mRNA	U94344.1	AAB62734.1