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    URB2 Urb2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853498, updated on 6-May-2012
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    Summary

    Gene symbol
    URB2
    Gene description
    Urb2p
    Primary source
    SGD:S000003802
    Locus tag
    YJR041C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NPA2
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    Genomic context

    Location :
    chromosome: X
    Sequence :
    Chromosome: X; NC_001142.9 (510239..513763, complement)
    See URB2 in MapViewer

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Gef1p Neighboring gene Nup85p Neighboring gene Pol32p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S pre-rRNA processing. Sahasranaman A, et al. EMBO J, 2011 Sep 16. PMID 21926967.
    2. Composition of yeast snRNPs and snoRNPs in the absence of trimethylguanosine caps reveals nuclear cap binding protein as a gained U1 component implicated in the cold-sensitivity of tgs1Δ cells. Schwer B, et al. Nucleic Acids Res, 2011 Aug. PMID 21558325.
    3. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, et al. Mol Cell Proteomics, 2011 May. PMID 21427232.
    4. Role and dynamics of the ribosomal protein P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces cerevisiae. Rodríguez-Mateos M, et al. Nucleic Acids Res, 2009 Dec. PMID 19789271.
    5. An atlas of chaperone-protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell. Gong Y, et al. Mol Syst Biol, 2009. PMID 19536198.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. These results support the idea that Npa2p, Dbp6p, Npa1p, Nop8p, and Rsa3p work in concert during the early steps of 60S subunit biogenesis.
      Title: Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:33792 BioGRID:36005 CBC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:35864 DBP6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:34156 DBP7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:31544 DBP9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33792 BioGRID:32699 HTA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:31610 KAP95    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:36516 LRP1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:33792 BioGRID:34698 NOP58    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:31832 NOP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:34273 NOP8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33792 BioGRID:33959 RPL17A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:33584 RPL17B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:34462 RPL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:36050 RPL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:36389 RPL8A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:31269 RPL8B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33792 BioGRID:31488 RSA3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Synthetic Lethality 
    BioGRID:33792 BioGRID:35644 SRP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:31882 SSB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:35302 STO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:34118 URB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33792 BioGRID:32441 YRA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33792 BioGRID:33951 YRA2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    rRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ribosome biogenesis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Urb2p
    NP_012575.1
    • Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9

      Range
      510239..513763, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181699.1 → NP_012575.1  Urb2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P47108
      Conserved Domains (1) summary
      pfam10441
      Location:960 – 1173
      Blast Score: 556
      Urb2; Urb2/Npa2 family
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006943.2 DAA08828.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47108.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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