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    COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) [ Homo sapiens ]

    Gene ID: 8533, updated on 11-May-2012
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    Summary

    Official Symbol
    COPS3provided by HGNC
    Official Full Name
    COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)provided by HGNC
    Primary source
    HGNC:2239
    See related
    Ensembl:ENSG00000141030; HPRD:07262; MIM:604665; Vega:OTTHUMG00000059281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSN3; SGN3
    Summary
    The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
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    Genomic context

    Location :
    17p11.2
    Sequence :
    Chromosome: 17; NC_000017.10 (17149938..17184617, complement)
    See COPS3 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene POTE ankyrin domain family, member I pseudogene Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene ribosomal protein L13 pseudogene 12

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Global identification of modular cullin-RING ligase substrates. Emanuele MJ, et al. Cell, 2011 Oct 14. PMID 21963094.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. Yan T, et al. Cancer Gene Ther, 2011 Jun. PMID 21436869.

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
      Title: RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003644.2 NP_001645.1 ARAF    BIND  PubMed A-RAF interacts with SGN3. 
    NP_003644.2 NP_001645.1 ARAF    BIND  PubMed ARAF (A-Raf) interacts with COPS3 (SGN3). 
    NP_003644.2 AAD43021.1 COPS4    BIND  PubMed CSN4 interacts with CSN3. 
    NP_003644.2 AAD03469.1 COPS6    BIND  PubMed CSN6 interacts with CSN3. 
    NP_003644.2 NP_006701.1 COPS8    BIND  PubMed CSN8 interacts with CSN3. 
    NP_003644.2 NP_071888.1 MLF1    BIND  PubMed MLF1 interacts with COPS3 (CSN3). 
    NP_003644.2 NP_002871.1 RAF1    BIND  PubMed C-RAF interacts with SGN3. 
    NP_003644.2 NP_002871.1 RAF1    BIND  PubMed RAF1 (C-Raf) interacts with COPS3 (SGN3). 
    Q9UNS2 P10398 ARAF    HPRD  PubMed  
    Q9UNS2 P61201 COPS2    HPRD  PubMed  
    Q9UNS2 Q9BT78 COPS4    HPRD  PubMed  
    Q9UNS2 Q92905 COPS5    HPRD  PubMed  
    Q9UNS2 Q7L5N1 COPS6    HPRD  PubMed  
    Q9UNS2 Q9UBW8 COPS7A    HPRD  PubMed  
    Q9UNS2 Q99627 COPS8    HPRD  PubMed  
    Q9UNS2 Q93034 CUL5    HPRD  PubMed  
    Q9UNS2 Q13098 GPS1    HPRD  PubMed  
    Q9UNS2 Q9Y6K9 IKBKG    HPRD  PubMed  
    Q9UNS2 P05107 ITGB2    HPRD  PubMed  
    Q9UNS2 Megalin binding protein LRP2BP    HPRD  PubMed  
    Q9UNS2 P58340 MLF1    HPRD  PubMed  
    Q9UNS2 P04049 RAF1    HPRD  PubMed  
    Q9UNS2 P04637 TP53    HPRD  PubMed  
    BioGRID:114103 BioGRID:106864 ARAF    BioGRID  PubMed Two-hybrid 
    BioGRID:114103 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:114103 BioGRID:114103 COPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:119324 COPS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:116176 COPS6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:119130 COPS7A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:122237 COPS7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:116124 COPS8    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:114103 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114103 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:114028 CUL4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:199074 Ddb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:109131 GPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114103 BioGRID:114089 IKBKG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114103 BioGRID:111282 PHYH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:111715 PTGS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114103 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114103 BioGRID:119068 WRAP73    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cullin deneddylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to light stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    COP9 signalosome complex subunit 3
    Names
    COP9 signalosome complex subunit 3
    signalosome subunit 3
    COP9 complex subunit 3
    JAB1-containing signalosome subunit 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199125.1 → NP_001186054.1  COP9 signalosome complex subunit 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC055811, AK302304, BU952436
      Consensus CDS
      CCDS56022.1
      UniProtKB/TrEMBL
      B4DY81
      UniProtKB/Swiss-Prot
      Q9UNS2
      Related
      ENSP00000437606, ENST00000539941
      Conserved Domains (1) summary
      cl02111
      Location:240 – 340
      Blast Score: 205
      PCI; PCI domain

    2. NM_003653.3 → NP_003644.2  COP9 signalosome complex subunit 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC055811, BC001891, BP260214, BU952436
      Consensus CDS
      CCDS11183.1
      UniProtKB/Swiss-Prot
      Q9UNS2
      Related
      ENSP00000268717, OTTHUMP00000065517, ENST00000268717, OTTHUMT00000131603
      Conserved Domains (1) summary
      cl02111
      Location:260 – 360
      Blast Score: 205
      PCI; PCI domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      17149938..17184617, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      16902830..16937477, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC055811.20 (109238..143690) None
    genomic CH471196.2 EAW55711.1
      EAW55712.1
      EAW55713.1
    mRNA AF031647.1 AAC14197.1
    mRNA AF098109.1 AAD41247.1
    mRNA AK297706.1 BAG60063.1
    mRNA AK302304.1 BAG63643.1
    mRNA AK312476.1 BAG35380.1
    mRNA AK316400.1 BAH14771.1
    mRNA BC001891.1 AAH01891.1
    mRNA BP260214.1 None
    mRNA BQ018146.1 None
    mRNA BU952436.1 None
    other-genetic HQ447242.1 ADQ31729.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNS2.3 GenPept UniProtKB/Swiss-Prot:Q9UNS2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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