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    SNA3 Sna3p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853290, updated on 31-Jan-2012
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    Summary

    Gene symbol
    SNA3
    Gene description
    Sna3p
    Primary source
    SGD:S000003687
    Locus tag
    YJL151C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: X; NC_001142.9 (136372..136773, complement)
    See SNA3 in MapViewer

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Vps35p Neighboring gene Ino1p Neighboring gene Das1p Neighboring gene ncRNA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Sites of ubiquitin attachment in Saccharomyces cerevisiae. Starita LM, et al. Proteomics, 2012 Jan. PMID 22106047.
    2. Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1. Creamer TJ, et al. PLoS Genet, 2011 Oct. PMID 22028667.
    3. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Magtanong L, et al. Nat Biotechnol, 2011 May 15. PMID 21572441.
    4. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, et al. Mol Cell Proteomics, 2011 May. PMID 21427232.
    5. Structure and function of a HECT domain ubiquitin-binding site. Kim HC, et al. EMBO Rep, 2011 Apr. PMID 21399621.

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Sna3 is a potential competitor of Bul1 for the Rsp5 WW domain affecting degradation of tryptophan permease Tat2.
      Title: Overexpression of Sna3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1.
    2. Sna3p undergoes Rsp5-dependent polyubiquitylation with K63-linked ubiquitin chains during its sorting to the endosomal pathway.
      Title: Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation.
    3. Sna3 circumvents Ub-mediated recognition by interacting directly with Rsp5, an E3 Ub ligase that catalyzes monoubiquitination of multivesicular bodies vesicle cargoes.
      Title: Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.
    4. These results uncover a series of determinants impacting Sna3 multivesicular bodies sorting, including unexpected roles for Rsp5.
      Title: Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.
    5. Sna3p sorting depends on a direct interaction between a PPAY motif within its C-terminal cytosolic tail and the WW domains of Rsp5p.
      Title: Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:33608 BioGRID:31413 ACF2    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31853 ARF1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:34846 ATG32    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:34867 AYR1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36547 BZZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:31937 CDC48    BioGRID  PubMed Dosage Rescue 
    BioGRID:33608 BioGRID:36907 COG3    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32415 EAF1    BioGRID  PubMed Positive Genetic 
    BioGRID:33608 BioGRID:32876 EHT1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31374 ERG27    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36505 ERG7    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32742 FAT1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31884 GCS1    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:35029 GTT1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31004 HSP30    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36528 HXT1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36038 KES1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:34962 KRE27    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:35476 LCB1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31177 LSB3    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:34139 MEH1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32184 MTC5    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:33300 MUP1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33608 BioGRID:35993 NAB3    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33608 BioGRID:35765 OCA2    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:36122 PDR12    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32552 PLM2    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32953 POP4    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:34832 POT1    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:32703 RER2    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31209 RET2    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33291 RME1    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:36869 RSP5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:33608 BioGRID:35255 SEC14    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:35550 SEC21    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32289 SEC26    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33115 SEC27    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32692 SLA1    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:32007 SLC1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32242 SLY1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33608 SNA3    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:35631 SPS18    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:32957 TAE1    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:33996 TGL1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:32961 TSC10    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33608 BioGRID:35156 UBX2    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36717 VAC8    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33044 VAM7    BioGRID  PubMed Negative Genetic; Two-hybrid 
    BioGRID:33608 BioGRID:36214 VMA13    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33262 VMA7    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36678 VMA8    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:33606 VPS35    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36308 VPS66    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:35046 VPS9    BioGRID  PubMed Two-hybrid 
    BioGRID:33608 BioGRID:31025 YCR043C    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:31062 YCR090C    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:31095 YFL052W    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:35327 YIM1    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:34039 YJU3    BioGRID  PubMed PCA 
    BioGRID:33608 BioGRID:36259 YPR089W    BioGRID  PubMed Negative Genetic 
    BioGRID:33608 BioGRID:36445 YSC84    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin protein ligase binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    endosome transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    vacuolar lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Sna3p
    NP_012384.1
    • Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9

      Range
      136372..136773, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181584.1 → NP_012384.1  Sna3p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P14359
      Conserved Domains (1) summary
      cl00431
      Location:17 – 72
      Blast Score: 174
      Pmp3; Proteolipid membrane potential modulator
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006943.2 DAA08651.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P14359.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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