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SOP4 Sop4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853247, updated on 27-Jan-2024

Summary

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Gene symbol
SOP4
Gene description
Sop4p
Primary source
SGD:S000003728
Locus tag
YJL192C
See related
AllianceGenome:SGD:S000003728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
EMC7
Summary
Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (72710..73414, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene AAA family ATPase CDC6 Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S14B Neighboring gene ribosomal 40S subunit protein S22A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? Wideman JG. F1000Res, 2015. PMID 26512320, Free PMC Article
  2. An ER membrane protein, Sop4, facilitates ER export of the yeast plasma membrane [H+]ATPase, Pma1. Luo WJ, et al. Traffic, 2002 Oct. PMID 12230471
  3. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
  4. Molecular characterization of propolis-induced cell death in Saccharomyces cerevisiae. de Castro PA, et al. Eukaryot Cell, 2011 Mar. PMID 21193549, Free PMC Article
  5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sop4p
NP_012343.1
  • ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    72710..73414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181625.1 → NP_012343.1  TPA: Sop4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012343.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQE4, D6VVZ9, P39543
    UniProtKB/TrEMBL
    A0A8H4FAM1, B3LPT5, B5VL00, C8ZB28, G2WGI5, N1P157
    Conserved Domains (1) summary
    pfam17081
    Location:24 → 227
    SOP4; Suppressor of PMA 1-7 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39543.1

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