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YIP1 transporter YIP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853082, updated on 4-Feb-2024

Summary

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Gene symbol
YIP1
Gene description
transporter YIP1
Primary source
SGD:S000003404
Locus tag
YGR172C
See related
AllianceGenome:SGD:S000003404
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Is integral component of Golgi membrane. Orthologous to several human genes including YIPF5 (Yip1 domain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (842845..843591, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene Rbg2p Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis and properties of the yeast YIP1 family of Ypt-interacting proteins. Chen CZ, et al. Methods Enzymol, 2005. PMID 16473599
  2. Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response. Taguchi Y, et al. Cell Death Dis, 2017 Mar 30. PMID 28358375, Free PMC Article
  3. Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Heidtman M, et al. Mol Biol Cell, 2005 Apr. PMID 15659647, Free PMC Article
  4. The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles. Barrowman J, et al. J Biol Chem, 2003 May 30. PMID 12657649
  5. Perinuclear localization of chromatin facilitates transcriptional silencing. Andrulis ED, et al. Nature, 1998 Aug 6. PMID 9707122

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present study is the first to uncover a key prosurvival modulator, Yip1A, which coordinates IRE1 signaling with PERK signaling to support the survival of HeLa and CaSki cervical cancer cells.
    Title: Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response.
  2. Yos1p associates with Yip1p and Yif1p, indicating Yos1p is a novel subunit of the Yip1p-Yif1p complex
    Title: Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.
  3. Rab requirement is confined to a subset of Rab proteins that are localized to the Golgi apparatus.
    Title: Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in COPII-coated ER to Golgi transport vesicle IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transporter YIP1
NP_011688.3
  • Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    842845..843591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181301.3 → NP_011688.3  TPA: transporter YIP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011688.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUV6, P53039
    UniProtKB/TrEMBL
    A0A8H4C0T0, C7GQ79, N1P9X6
    Conserved Domains (1) summary
    COG5080
    Location:3 → 248
    YIP1; Rab GTPase interacting factor, Golgi membrane protein [Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53039.1

Gene LinkOut

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