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POP6 ribonuclease P/MRP protein subunit POP6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852918, updated on 13-Apr-2024

Summary

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Gene symbol
POP6
Gene description
ribonuclease P/MRP protein subunit POP6
Primary source
SGD:S000003262
Locus tag
YGR030C
See related
AllianceGenome:SGD:S000003262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables rRNA primary transcript binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex; ribonuclease MRP complex; and telomerase holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See POP6 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (545681..546157, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene ncRNA Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene 1,3-beta-glucan synthase GSC2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Eukaryotic ribonucleases P/MRP: the crystal structure of the P3 domain. Perederina A, et al. EMBO J, 2010 Feb 17. PMID 20075859, Free PMC Article
  2. Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. Fagerlund RD, et al. RNA, 2015 Sep. PMID 26135751, Free PMC Article
  3. Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7. Perederina A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jan 1. PMID 20057077, Free PMC Article
  4. A new role for proteins subunits of RNase P: stabilization of the telomerase holoenzyme. Garcia PD, et al. Microb Cell, 2020 Jun 17. PMID 32904320, Free PMC Article
  5. Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs. Perederina A, et al. RNA, 2007 Oct. PMID 17717080, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In pop mutants, TLC1 is more abundant, telomeres are short, and TLC1 accumulates in the cytoplasm. Although Est1/2 binding to TLC1 occurs at normal levels, Est1 (and hence Est3) binding is highly unstable.
    Title: Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP.
  2. Study reports that the Pop1, Pop6, and Pop7 proteins, known components of RNase P and RNase MRP, bind to yeast telomerase RNA and are essential constituents of the telomerase holoenzyme.
    Title: Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP.
  3. Crystal of Pop6 (18.2 kDa) and Pop7 (15.8 kDa) were obtained. They belonged to space group P4(2)22 (unit-cell parameters a = b = 127.2, c = 76.8 A, alpha = beta = gamma = 90 degrees ) and diffracted to 3.25 A resolution
    Title: Crystallization and preliminary X-ray diffraction analysis of the P3 RNA domain of yeast ribonuclease MRP in a complex with RNase P/MRP protein components Pop6 and Pop7.
  4. Footprint analysis of the interaction between the Pop6/7 heterodimer and the RNase mitochondrial RNA-processing RNA, combined with gel mobility assays, demonstrates that the Pop6/7 complex binds to a conserved region of the P3 domain.
    Title: Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA primary transcript binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease MRP activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ribonuclease P activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ribonuclease P activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intronic box C/D snoRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease MRP complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease P/MRP protein subunit POP6
NP_011544.1
  • Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    545681..546157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181159.1 → NP_011544.1  TPA: ribonuclease P/MRP protein subunit POP6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUG5, P53218
    UniProtKB/TrEMBL
    A0A6V8RJK5, E9P995, G2WEC0, N1P9U6
    Conserved Domains (1) summary
    pfam01918
    Location:49 → 118
    Alba
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6AGB_F.1
6AH3_F.1
6W6V_F.1
7C79_F.1
7C7A_F.1
P53218.1

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