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    TFG2 Tfg2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852888, updated on 5-Feb-2012
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    Summary

    Gene symbol
    TFG2
    Gene description
    Tfg2p
    Primary source
    SGD:S000003237
    Locus tag
    YGR005C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: VII; NC_001139.9 (504657..505859, complement)
    See TFG2 in MapViewer

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Cul3p Neighboring gene Pex31p Neighboring gene Prp18p Neighboring gene Ect1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Structural and binding studies of the C-terminal domains of yeast TFIIF subunits Tfg1 and Tfg2. Kilpatrick AM, et al. Proteins, 2011 Oct 12. PMID 22095626.
    2. Novel interactions between actin and the proteasome revealed by complex haploinsufficiency. Haarer B, et al. PLoS Genet, 2011 Sep. PMID 21966278.
    3. Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. Ren L, et al. PLoS One, 2011 Feb 28. PMID 21386897.
    4. Highly reproducible label free quantitative proteomic analysis of RNA polymerase complexes. Mosley AL, et al. Mol Cell Proteomics, 2011 Feb. PMID 21048197.
    5. A global protein kinase and phosphatase interaction network in yeast. Breitkreutz A, et al. Science, 2010 May 21. PMID 20489023.

    See all (43) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Tfg2p is retained in the nucleus through DNA binding in Saccharomyces cerevisiae.
      Title: Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus.
    2. We show that Anc1 is required for growth on galactose as the sole carbon source, and that it is recruited to the UAS of the GAL1 gene after induction.
      Title: Anc1 interacts with the catalytic subunits of the general transcription factors TFIID and TFIIF, the chromatin remodeling complexes RSC and INO80, and the histone acetyltransferase complex NuA3.
    3. Evidence that the Tfg1/Tfg2 dimer interface of TFIIF is located in proximity to the B-finger of TFIIB near the active center of RNA polymerase II (RNAP II) where the TFIIB-TFIIF-RNAP II interface plays a key role in transcription start site selection.
      Title: Evidence that the Tfg1/Tfg2 dimer interface of TFIIF lies near the active center of the RNA polymerase II initiation complex.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_011519.1 NC_001147.4 ADH1    BIND  PubMed Tfg2 interacts with ADH1 
    BioGRID:33249 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Haploinsufficiency 
    BioGRID:33249 BioGRID:32891 AIM4    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:33249 BioGRID:34950 APQ12    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31358 ARP6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36905 BEM2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31987 BRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31289 BRE2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35876 BRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:34429 BUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31963 BUG1    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:31745 CCR4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:31676 CDC73    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:33249 BioGRID:32304 CHL4    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:34441 CKB2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35070 COG8    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35835 CSE2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:36302 CTF4    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35989 DDC1    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:31148 DEG1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33952 DOA1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33205 DST1    BioGRID  PubMed Affinity Capture-MS; Co-purification; Negative Genetic 
    BioGRID:33249 BioGRID:33453 ELP2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36095 ELP3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36079 ELP4    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35492 ELP6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35161 ERG6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:34353 GAL11    BioGRID  PubMed Affinity Capture-Western; Negative Genetic 
    BioGRID:33249 BioGRID:30970 GBP2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35635 GCR2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35676 GIM3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36673 HAT2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32192 HPR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:35923 HSP82    BioGRID  PubMed Two-hybrid 
    BioGRID:33249 BioGRID:34392 HTZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33086 HUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35621 IES2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:34584 IES4    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31947 IWR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:32720 KAP104    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:33249 BioGRID:32999 KAP114    BioGRID  PubMed Reconstituted Complex 
    BioGRID:33249 BioGRID:36056 KAP120    BioGRID  PubMed Reconstituted Complex 
    BioGRID:33249 BioGRID:36125 LGE1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36516 LRP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:33249 BioGRID:32437 LSM6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32296 MNN10    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33579 MNN11    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35541 MON2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35402 MRE11    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33249 BioGRID:36227 NHP6A    BioGRID  PubMed PCA 
    BioGRID:33249 BioGRID:32795 NHP6B    BioGRID  PubMed PCA; Reconstituted Complex 
    BioGRID:33249 BioGRID:31612 ORM2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36737 PAC2    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:32973 PAF1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:33249 BioGRID:33383 PRE9    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35488 PSE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:33249 BioGRID:35250 RCO1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31315 RIC1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33610 RPA34    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:34605 RPB10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:34399 RPB11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33249 BioGRID:34547 RPB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:33249 BioGRID:34967 RPB3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33249 BioGRID:33617 RPB4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Positive Genetic 
    BioGRID:33249 BioGRID:32853 RPB5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33249 BioGRID:32464 RPB7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33249 BioGRID:34618 RPB8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:33178 RPB9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:31921 RPO21    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:33249 BioGRID:36359 RPO26    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:33249 BioGRID:34404 RRP6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36869 RSP5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:31249 RTT109    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32210 SAC3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35441 SAP30    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32646 SAS3    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:32235 SAS4    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:32522 SDC1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32782 SEC18    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:33249 BioGRID:31536 SEC22    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32420 SEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33591 SET2    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33651 SET4    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33181 SGF73    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36361 SKI3    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:36698 SPF1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32454 SPT3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33308 SPT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:35159 SPT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:31330 SPT8    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36473 SRB2    BioGRID  PubMed Co-purification 
    BioGRID:33249 BioGRID:36756 SRB4    BioGRID  PubMed Co-purification 
    BioGRID:33249 BioGRID:33347 SRB5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:32948 SRB6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:30946 SRO9    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31278 SSL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33249 BioGRID:36257 SUA7    BioGRID  PubMed Co-purification 
    BioGRID:33249 BioGRID:31755 SWC3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32926 SWC5    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32874 SWD3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:33585 SWI3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36856 SWI4    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32391 SWR1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32457 SXM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:33249 BioGRID:36052 TAF14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Synthetic Growth Defect 
    BioGRID:33249 BioGRID:36230 TFB4    BioGRID  PubMed Co-purification 
    BioGRID:33249 BioGRID:33438 TFG1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Synthetic Growth Defect 
    BioGRID:33249 BioGRID:34329 THP1    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36601 THP2    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:35981 TPK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:35539 TRF5    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32166 TRS85    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32149 UBC13    BioGRID  PubMed PCA 
    BioGRID:33249 BioGRID:36719 UBC8    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:36901 UBP3    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31160 UBP6    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31298 UBR2    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:34122 UFD4    BioGRID  PubMed Positive Genetic 
    BioGRID:33249 BioGRID:33315 UPF3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:36319 URN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33249 BioGRID:31633 VID22    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:35128 VPS71    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:32537 VPS72    BioGRID  PubMed Negative Genetic 
    BioGRID:33249 BioGRID:31529 YPT6    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    core RNA polymerase II binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to core RNA polymerase II recruiting transcription factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA polymerase II transcriptional preinitiation complex assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    promoter clearance from RNA polymerase II promoter IC
    Inferred by Curator
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor TFIIF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor TFIIF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Tfg2p
    NP_011519.1
    • TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9

      Range
      504657..505859, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181134.1 → NP_011519.1  Tfg2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41896
      Conserved Domains (1) summary
      cl02122
      Location:56 – 357
      Blast Score: 756
      TFIIF_beta; Transcription initiation factor IIF, beta subunit
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006941.2 DAA08103.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P41896.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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