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    MPT5 Mpt5p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852697, updated on 6-May-2012
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    Summary

    Gene symbol
    MPT5
    Gene description
    Mpt5p
    Primary source
    SGD:S000003146
    Locus tag
    YGL178W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HTR1; PUF5; UTH4
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    Genomic context

    Location :
    chromosome: VII
    Sequence :
    Chromosome: VII; NC_001139.9 (167352..170571)
    See MPT5 in MapViewer

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Atg1p Neighboring gene Tos3p Neighboring gene hypothetical protein Neighboring gene Sae2p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression. Zimmermann C, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22042866.
    2. Divergent RNA binding specificity of yeast Puf2p. Yosefzon Y, et al. RNA, 2011 Aug. PMID 21685478.
    3. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, et al. Mol Cell Proteomics, 2011 May. PMID 21427232.
    4. Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Cridge AG, et al. Nucleic Acids Res, 2010 Dec. PMID 20705650.
    5. The yeast PUF protein Puf5 has Pop2-independent roles in response to DNA replication stress. Traven A, et al. PLoS One, 2010 May 14. PMID 20498834.

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mpt5 represses the protein levels of two pathway components, the Ste7 MAP-kinase kinase and the Tec1 transcriptional activator, and negatively regulates the kinase activity of the Kss1 MAP kinase even in the absence of stimuli.
      Title: Control of signaling in a MAP-kinase pathway by an RNA-binding protein.
    2. mutations in BRR1 or MPT5 lead to a restoration of fertility and a more-or-less pronounced restoration of polarity; they also show genetic interactions with SSD1.
      Title: Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BAA05172.1 NP_009537.1 FUS3    BIND  PubMed Fus3 interacts with Mpt5. 
    BAA05172.1 NP_011554.1 KSS1    BIND  PubMed Kss1 interacts with Mpt5. 
    BAA05172.1 NP_013557.1 SST2    BIND  PubMed Sst2 interacts with Mpt5. 
    NP_011337.1 NP_009718.1 CDC28    BIND  PubMed Cdc28p interacts with Mpt5p. 
    BioGRID:33076 BioGRID:36231 BRR1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:33076 BioGRID:36547 BZZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:33076 BioGRID:34665 CAF20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:33076 BioGRID:35549 CAF40    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:35668 CBK1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:33076 BioGRID:31745 CCR4    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:33076 BioGRID:32859 CDC28    BioGRID  PubMed Affinity Capture-Western; Synthetic Growth Defect; Two-hybrid 
    BioGRID:33076 BioGRID:31065 CDC39    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:31903 DHH1    BioGRID  PubMed PCA; Synthetic Growth Defect 
    BioGRID:33076 BioGRID:32682 FUS3    BioGRID  PubMed Affinity Capture-Western; Synthetic Rescue; Two-hybrid 
    BioGRID:33076 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33076 BioGRID:31883 HO    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:33076 BioGRID:31211 HXK1    BioGRID  PubMed Protein-RNA 
    BioGRID:33076 BioGRID:33845 JSN1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:33076 BioGRID:33287 KSS1    BioGRID  PubMed Two-hybrid 
    BioGRID:33076 BioGRID:31871 LRG1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:33076 BioGRID:36857 LSM4    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:33157 PAN2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:33076 BioGRID:32598 PKC1    BioGRID  PubMed Dosage Rescue 
    BioGRID:33076 BioGRID:35877 POP2    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue; PCA; Synthetic Growth Defect 
    BioGRID:33076 BioGRID:35810 PUB1    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:31210 RPN12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33076 BioGRID:36755 RPN3    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:32017 SIR2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:33076 BioGRID:31701 SIR3    BioGRID  PubMed Synthetic Rescue 
    BioGRID:33076 BioGRID:32279 SIR4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:33076 BioGRID:34412 SLG1    BioGRID  PubMed Dosage Rescue 
    BioGRID:33076 BioGRID:36461 SLT2    BioGRID  PubMed Dosage Rescue 
    BioGRID:33076 BioGRID:30946 SRO9    BioGRID  PubMed PCA 
    BioGRID:33076 BioGRID:32345 SSD1    BioGRID  PubMed PCA; Phenotypic Enhancement; Synthetic Lethality 
    BioGRID:33076 BioGRID:31710 SST2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:33076 BioGRID:31419 STM1    BioGRID  PubMed Dosage Rescue 
    BioGRID:33076 BioGRID:33575 SWE1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:33076 BioGRID:36856 SWI4    BioGRID  PubMed Synthetic Lethality 
    BioGRID:33076 BioGRID:34190 TIF1    BioGRID  PubMed Protein-RNA 
    BioGRID:33076 BioGRID:33615 TIM17    BioGRID  PubMed Dosage Rescue 
    BioGRID:33076 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:33076 BioGRID:35636 WHI3    BioGRID  PubMed Protein-RNA 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of chromatin silencing involved in replicative cell aging IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    negative regulation of chromatin silencing involved in replicative cell aging IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of chromatin silencing involved in replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		  
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    re-entry into mitotic cell cycle after pheromone arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Mpt5p
    NP_011337.1
    • Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9

      Range
      167352..170571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181043.1 → NP_011337.1  Mpt5p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P39016
      Conserved Domains (2) summary
      COG5099
      Location:49 – 848
      Blast Score: 1078
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
      cd07920
      Location:208 – 554
      Blast Score: 833
      Pumilio; Pumilio-family RNA binding domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006941.2 DAA07936.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39016.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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