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COG1 Golgi transport complex subunit COG1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852649, updated on 13-Apr-2024

Summary

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Gene symbol
COG1
Gene description
Golgi transport complex subunit COG1
Primary source
SGD:S000003191
Locus tag
YGL223C
See related
AllianceGenome:SGD:S000003191
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COD3; LDB11; SEC36
Summary
Enables protein-macromolecule adaptor activity. Involved in Golgi organization; cytoplasm to vacuole transport by the Cvt pathway; and retrograde transport, vesicle recycling within Golgi. Part of Golgi transport complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (79112..80365, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene GDP-mannose transporter Neighboring gene nucleotidase Neighboring gene Edc1p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. Chatterton JE, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927668, Free PMC Article
  2. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Shemorry A, et al. Mol Cell, 2013 May 23. PMID 23603116, Free PMC Article
  3. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article
  4. Detailed Analysis of the Interaction of Yeast COG Complex. Ishii M, et al. Cell Struct Funct, 2018 Jul 19. PMID 29899178, Free PMC Article
  5. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron interacts with Cog2, Cog3 and Cog4.
    Title: Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
  2. Cog1p has a critical role in the organization of the yeast conserved oligomeric Golgi complex
    Title: Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Golgi transport complex subunit COG1
NP_011292.1
  • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    79112..80365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181088.1 → NP_011292.1  TPA: Golgi transport complex subunit COG1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011292.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVB2, P53079
    UniProtKB/TrEMBL
    A0A8H4C2B0, C7GUZ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53079.1

Gene LinkOut

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