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HXK2 hexokinase 2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 852639, updated on 19-Oct-2014
Gene symbol
HXK2
Gene description
hexokinase 2
Primary source
SGD:S000003222
Locus tag
YGL253W
Gene type
protein coding
RNA name
hexokinase 2
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HEX1; HKB; SCI2
See HXK2 in MapViewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (23935..25395)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene high-affinity Zn(2+) transporter ZRT1 Neighboring gene Fzf1p Neighboring gene Rtg2p Neighboring gene Hfm1p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
fructose import IGI
Inferred from Genetic Interaction
more info
PubMed 
fructose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose import IGI
Inferred from Genetic Interaction
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hexose metabolic process IEA
Inferred from Electronic Annotation
more info
 
mannose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by glucose IDA
Inferred from Direct Assay
more info
PubMed 
replicative cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
hexokinase 2
NP_011261.1
  • Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 

    Range
    23935..25395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181119.1NP_011261.1  hexokinase 2 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_011261.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P04807
    Conserved Domains (3) summary
    cd00012
    Location:83241
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    COG5026
    Location:6478
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam03727
    Location:225458
    Hexokinase_2; Hexokinase