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    GUS1 Gus1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852606, updated on 4-Feb-2012
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    Summary

    Gene symbol
    GUS1
    Gene description
    Gus1p
    Primary source
    SGD:S000003214
    Locus tag
    YGL245W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GSN1
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    Genomic context

    Sequence :
    Chromosome: VII; NC_001139.9 (39023..41149)
    See GUS1 in MapViewer

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Brr6p Neighboring gene Rai1p Neighboring gene Rtf1p Neighboring gene Tad1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Echtenkamp FJ, et al. Mol Cell, 2011 Jul 22. PMID 21777812.
    2. An integrated approach to characterize genetic interaction networks in yeast metabolism. Szappanos B, et al. Nat Genet, 2011 May 29. PMID 21623372.
    3. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, et al. Genes Dev, 2011 Apr 1. PMID 21460040.
    4. A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis. Ziv I, et al. Mol Cell Proteomics, 2011 May. PMID 21427232.
    5. Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. Ren L, et al. PLoS One, 2011 Feb 28. PMID 21386897.

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. cytosolic glutamyl-tRNA synthetase ((c)ERS) is imported into mitochondria, where it constitutes the mitochondrial nondiscriminating ERS that generates the mitochondrial mischarged glutamyl-tRNA(Gln) substrate for the AdT
      Title: Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS.
    2. assembly of the Arc1p-synthetase complex is mediated exclusively by the N-terminal domains of the synthetases and that the two enzymes bind to largely independent sites on Arc1p.
      Title: Molecular determinants of the yeast Arc1p-aminoacyl-tRNA synthetase complex assembly.
    3. These results are consistent with a model according to which Arc1p is a bifunctional protein involved in the subcellular localization of ScMetRS and ScGluRS via its N-terminal domain and of tRNA via its C-terminal domain.
      Title: Arc1p is required for cytoplasmic confinement of synthetases and tRNA.
    4. The structure of the interacting domain of yeast glutamyl-tRNA synthetase (GluRS) and its accessory protein Arc1p was determined and refined to 1.9 A resolution.
      Title: Structures of the interacting domains from yeast glutamyl-tRNA synthetase and tRNA-aminoacylation and nuclear-export cofactor Arc1p reveal a novel function for an old fold.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32995 BioGRID:35258 ADH3    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:32891 AIM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33145 ARC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Synthetic Lethality 
    BioGRID:32995 BioGRID:32914 ATG12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:32350 ATP5    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:33662 BCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:30954 BIK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35876 BRE5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:30969 BUD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31696 CAR2    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:36540 CDC12    BioGRID  PubMed Affinity Capture-MS; Synthetic Growth Defect 
    BioGRID:32995 BioGRID:31801 CDC15    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:33460 CIR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34306 COQ3    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:35222 CSM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34214 DAD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33335 DBF2    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:32025 DBP10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:32532 DIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31892 DLD1    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:35002 DSN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35223 ERB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36801 FCY21    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:34141 FOX2    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:36041 FRK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:30943 GLK1    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:36754 GPA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36390 GUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:34837 GUT2    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35066 HMG1    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:34392 HTZ1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33697 IKS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:36830 ILV1    BioGRID  PubMed Affinity Capture-MS; Positive Genetic 
    BioGRID:32995 BioGRID:33650 IME2    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:36513 IRE1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:30960 KCC4    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:31063 KIN82    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:36517 KSP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:33287 KSS1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:32995 BioGRID:35779 LAP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35532 MCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:32836 MEC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33515 MES1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34337 MET22    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32995 BioGRID:35107 NTE1    BioGRID  PubMed Positive Genetic 
    BioGRID:32995 BioGRID:32736 PDX3    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:31819 PHO11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35082 PHO84    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:31966 PMT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36039 POC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34897 PRK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:34120 PRP40    BioGRID  PubMed Protein-peptide 
    BioGRID:32995 BioGRID:34019 PRR1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:32003 PSA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31749 PSK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:31959 QRI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36841 RAD51    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36030 RAD53    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:33096 RCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:34308 RFC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36188 RPA135    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36277 RPC40    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33849 RPL43B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36869 RSP5    BioGRID  PubMed Protein-peptide 
    BioGRID:32995 BioGRID:32030 RTK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34419 RTS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35927 RVB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34018 SBA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:32995 BioGRID:35451 SCS7    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:31439 SEC10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33115 SEC27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35234 SEN15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34287 SKM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:36152 SKS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:34025 SLD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31404 SLX4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:32573 SPS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32995 BioGRID:34959 SSM4    BioGRID  PubMed Protein-peptide 
    BioGRID:32995 BioGRID:36419 STE20    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:34051 TEF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35102 TEM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34480 TGL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33414 TIF4631    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:32827 TPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:36544 UBA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36901 UBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36319 URN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:33447 XKS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32995 BioGRID:36568 YCK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:32995 BioGRID:35675 YCK2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:32995 BioGRID:35983 YIG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34495 YOR097C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:35918 YPL245W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:34929 YRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:36106 YTA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32995 BioGRID:30998 tM(CAU)C    BioGRID  PubMed Protein-RNA 
    BioGRID:32995 BioGRID:34811 tM(CAU)Q1    BioGRID  PubMed Protein-RNA 
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    General gene information

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    glutamate-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glutamate-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity, forming aminoacyl-tRNA and related compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    glutamyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glutamyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    methionyl glutamyl tRNA synthetase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Gus1p
    NP_011269.2
    • Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9

      Range
      39023..41149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181111.1 → NP_011269.2  Gus1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P46655
      Conserved Domains (4) summary
      TIGR00463
      Location:102 – 696
      Blast Score: 2028
      gltX_arch; glutamyl-tRNA synthetase, archaeal and eukaryotic family
      cd10306
      Location:69 – 156
      Blast Score: 340
      GST_C_GluRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Glutamyl-tRNA synthetase
      pfam03950
      Location:509 – 681
      Blast Score: 326
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
      cl00015
      Location:369 – 511
      Blast Score: 577
      nt_trans; nucleotidyl transferase superfamily
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006941.2 DAA07874.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P46655.3 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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