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    PHO89 Pho89p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852599, updated on 21-May-2012
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    Summary

    Gene symbol
    PHO89
    Gene description
    Pho89p
    Primary source
    SGD:S000000500
    Locus tag
    YBR296C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ITN1
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    Genomic context

    Location :
    chromosome: II
    Sequence :
    Chromosome: II; NC_001134.8 (796798..798522, complement)
    See PHO89 in MapViewer

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Sul1p Neighboring gene Pca1p Neighboring gene hypothetical protein Neighboring gene Mal33p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. An integrated approach to characterize genetic interaction networks in yeast metabolism. Szappanos B, et al. Nat Genet, 2011 May 29. PMID 21623372.
    2. Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae. Ghillebert R, et al. Biochem J, 2011 Mar 1. PMID 21143198.
    3. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Bengtson MH, et al. Nature, 2010 Sep 23. PMID 20835226.
    4. Integrative responses to high pH stress in S. cerevisiae. Ariño J. OMICS, 2010 Oct. PMID 20726779.
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Even if Pho89 is synthesized in cells grown at pH 4.5-8.0, the transporter is functionally active under alkaline conditions only
      Title: Characterization of the Pho89 phosphate transporter by functional hyperexpression in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32989 BioGRID:35135 AMD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:33145 ARC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32989 BioGRID:35942 ATP15    BioGRID  PubMed Positive Genetic 
    BioGRID:32989 BioGRID:35020 DAL2    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:31526 GSY2    BioGRID  PubMed Positive Genetic 
    BioGRID:32989 BioGRID:35621 IES2    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:31212 IRC7    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:35683 MFA2    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:36566 NSG1    BioGRID  PubMed PCA 
    BioGRID:32989 BioGRID:35082 PHO84    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32989 BioGRID:31020 PHO87    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32989 BioGRID:33566 PHO90    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32989 BioGRID:35838 PHO91    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32989 BioGRID:33452 PMT6    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:34462 RPL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32989 BioGRID:34140 RSC4    BioGRID  PubMed Negative Genetic 
    BioGRID:32989 BioGRID:34475 SKI7    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32989 BioGRID:32225 SUP35    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32989 BioGRID:31224 TPO1    BioGRID  PubMed PCA 
    BioGRID:32989 BioGRID:35439 TPS3    BioGRID  PubMed Positive Genetic 
    BioGRID:32989 BioGRID:35731 YPT53    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    • Homologs of the PHO89 gene: The PHO89 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, , and N.crassa.

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    inorganic phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    sodium:inorganic phosphate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sodium:inorganic phosphate symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    phosphate ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphate ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Names
    Pho89p
    NP_009855.1
    • Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8

      Range
      796798..798522, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178644.1 → NP_009855.1  TPA: Pho89p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P38361
      Conserved Domains (1) summary
      cl00396
      Location:398 – 546
      Blast Score: 442
      PHO4; Phosphate transporter family
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006936.2 DAA07410.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38361.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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