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    CHK1 Chk1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852577, updated on 8-Jan-2012
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    Summary

    Gene symbol
    CHK1
    Gene description
    Chk1p
    Primary source
    SGD:S000000478
    Locus tag
    YBR274W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: II; NC_001134.8 (749594..751177)
    See CHK1 in MapViewer

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Hsm3p Neighboring gene Ubx7p Neighboring gene Rif1p Neighboring gene Pps1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Proteins in the nutrient-sensing and DNA damage checkpoint pathways cooperate to restrain mitotic progression following DNA damage. Searle JS, et al. PLoS Genet, 2011 Jul. PMID 21779180.
    2. Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Fasolo J, et al. Genes Dev, 2011 Apr 1. PMID 21460040.
    3. Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, et al. Science, 2010 Dec 3. PMID 21127252.
    4. Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae. Kaochar S, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21098663.
    5. Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Wood MD, et al. Cell Cycle, 2010 Aug 15. PMID 20716966.

    See all (52) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a single amino acid substitution in the C terminus, which could lead to an allosteric change in Chk1, allows it to bypass the requirement of the conserved ATR(Mec1) phosphorylation sites for checkpoint function.
      Title: ATRMec1 phosphorylation-independent activation of Chk1 in vivo.
    2. RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
      Title: The Saccharomyces cerevisiae checkpoint genes RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
    3. CHK1 mutants are not defective in double-strand break repair-initiated sister chromatid exchange, after exposure to DNA damaging agents.
      Title: Saccharomyces cerevisiae RAD53 (CHK2) but not CHK1 is required for double-strand break-initiated SCE and DNA damage-associated SCE after exposure to X rays and chemical agents.
    4. The observations in the chk1Delta/chk1Delta mutant strain suggest that constitutive nonhomologous end-joining is involved in the repair of BLM-induced DSBs.
      Title: Roles of Saccharomyces cerevisiae RAD17 and CHK1 checkpoint genes in the repair of double-strand breaks in cycling cells.
    5. Chk1p has a role in the intra-S-phase checkpoint activated when cells replicate their DNA
      Title: A role for Saccharomyces cerevisiae Chk1p in the response to replication blocks.
    6. Chk1-Pds1 checkpoint has roles in preventing tolerance of persistent single-strand breaks in Saccharomyces cerevisiae
      Title: Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_009833.1 NP_010398.1 PDS1    BIND  PubMed Chk1 interacts with Pds1. 
    NP_009833.1 NP_009501.1 SAS3    BIND  PubMed Sas3 interacts with Chk1. 
    BioGRID:32969 BioGRID:31107 ACT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:34020 APN1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:34950 APQ12    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:35861 ARC35    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31924 ARF2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33639 ASF1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Rescue 
    BioGRID:32969 BioGRID:36314 ASN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:32350 ATP5    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34957 BCY1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:33696 BIT61    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36930 BMH1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32969 BioGRID:31987 BRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32580 CAB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31696 CAR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:33817 CBF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31825 CDC13    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:32969 BioGRID:31182 CDC14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:32969 BioGRID:31724 CDC24    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31579 CDC3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32219 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:31376 CDC45    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32969 BioGRID:32038 CDC7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:36803 CEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32969 CHK1    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:34955 CKA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33352 CLB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36288 CLB5    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:33353 CLB6    BioGRID  PubMed Dosage Rescue 
    BioGRID:32969 BioGRID:36292 CTR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:31945 CYK3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33752 CYR1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32106 DBF4    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32969 BioGRID:34479 DIA2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:32462 DIT2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32124 DOA4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:31961 DUN1    BioGRID  PubMed Dosage Rescue; Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32969 BioGRID:32947 DUT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:36712 EAF5    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:33837 EAF6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:32876 EHT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:34541 ELG1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:33453 ELP2    BioGRID  PubMed Negative Genetic; Reconstituted Complex 
    BioGRID:32969 BioGRID:32567 EMI2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:36607 ENO2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:35398 ERG8    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32729 ETR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31564 EXG1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34435 EXO1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:31342 FYV7    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32722 GAL10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:32721 GAL7    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33503 GCN5    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34030 GFA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35433 GFD1    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:32559 GIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34342 GPD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:31526 GSY2    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:32276 HTB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:32700 HTB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:34392 HTZ1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35857 HUB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33026 HXK2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32840 IRA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:34321 IRA2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:32067 KCS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31369 KIN2    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:32495 LRS4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:33632 LSM1    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:33729 MAD2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32051 MCD1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32969 BioGRID:35532 MCK1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32836 MEC1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:32969 BioGRID:35683 MFA2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:30926 MRC1    BioGRID  PubMed Synthetic Lethality; Synthetic Rescue 
    BioGRID:32969 BioGRID:34183 MRS4    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34288 MSB4    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33680 NET1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35959 NEW1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32229 NGG1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:36511 NMD2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36313 NOC4    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35765 OCA2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32369 OMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33829 OPI3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32764 ORC2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36012 OYE3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:35343 PAH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32170 PDS1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:32969 BioGRID:31875 PHO13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:34393 PLB3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33210 PNC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:34832 POT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31927 PPH21    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36035 PPT2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36669 PRB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33941 PRS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:32064 PSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36834 PTC2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36036 PXA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36155 RAD1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:35379 RAD14    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31042 RAD18    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32969 BioGRID:35137 RAD52    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:36030 RAD53    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32270 RAD9    BioGRID  PubMed Phenotypic Suppression; Two-hybrid 
    BioGRID:32969 BioGRID:35547 RFC3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35734 RHO2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35629 RIO2    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:36195 RLF2    BioGRID  PubMed Phenotypic Enhancement; Synthetic Rescue 
    BioGRID:32969 BioGRID:36679 RML2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36188 RPA135    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:34724 RPA190    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35712 RPC19    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31979 RPL13A    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31455 RPL37A    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:31152 RPN11    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36462 RRM3    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:32673 RRN10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35448 RRN9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:34140 RSC4    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:32342 RTT103    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33953 SAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32646 SAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:35368 SGS1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:32017 SIR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:36861 SLX8    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35109 SML1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Rescue 
    BioGRID:32969 BioGRID:32529 SNF1    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:32851 SPP381    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35855 SSK2    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36137 SSN3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36146 SVL3    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35090 TAF8    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35200 TAP42    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34193 TFA2    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:35322 TIF34    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:34143 TOF2    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:32969 BioGRID:32511 TOM1    BioGRID  PubMed Positive Genetic 
    BioGRID:32969 BioGRID:33595 TPK1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:35981 TPK2    BioGRID  PubMed Affinity Capture-MS; Phenotypic Enhancement 
    BioGRID:32969 BioGRID:35331 TPP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32969 BioGRID:35871 TRM112    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:33954 TRP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:35141 TSA1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32969 BioGRID:33955 UBA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32969 BioGRID:31645 VAC14    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36678 VMA8    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:32103 VMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:34659 VPH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:36815 VTC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33211 YGL036W    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33552 YJL206C    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:33768 YJR011C    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35464 YKU70    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32969 BioGRID:31421 YLR152C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35278 YMR102C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32969 BioGRID:35604 YNL234W    BioGRID  PubMed Two-hybrid 
    BioGRID:32969 BioGRID:34621 YOR228C    BioGRID  PubMed Negative Genetic 
    BioGRID:32969 BioGRID:35452 ZDS1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32969 BioGRID:35095 ZDS2    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Homology

    • Homologs of the CHK1 gene: The CHK1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, and N.crassa.

    Pathways from BioSystems

    • Cell cycle - yeast, organism-specific biosystem (from KEGG)
      Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Cell cycle - yeast, conserved biosystem (from KEGG)
      Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
    • Meiosis - yeast, organism-specific biosystem (from KEGG)
      Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    • Meiosis - yeast, conserved biosystem (from KEGG)
      Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    replication fork protection IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Names
    Chk1p
    NP_009833.1
    • Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8

      Range
      749594..751177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178622.1 → NP_009833.1  TPA: Chk1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P38147
      Conserved Domains (2) summary
      cd00180
      Location:21 – 279
      Blast Score: 479
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:17 – 281
      Blast Score: 605
      S_TKc; Serine/Threonine protein kinases, catalytic domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006936.2 DAA07390.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P38147.1 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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