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    SLX1 Slx1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852529, updated on 8-Jan-2012
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    Summary

    Gene symbol
    SLX1
    Gene description
    Slx1p
    Primary source
    SGD:S000000432
    Locus tag
    YBR228W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: II; NC_001134.8 (675313..676227)
    See SLX1 in MapViewer

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Mcx1p Neighboring gene Rot2p Neighboring gene Om14p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Pathways for Holliday junction processing during homologous recombination in Saccharomyces cerevisiae. Ashton TM, et al. Mol Cell Biol, 2011 May. PMID 21343337.
    2. Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins. Scherrer T, et al. Genome Biol, 2011. PMID 21232131.
    3. DNA damage signaling recruits the Rtt107-Slx4 scaffolds via Dpb11 to mediate replication stress response. Ohouo PY, et al. Mol Cell, 2010 Jul 30. PMID 20670896.
    4. Post-replication repair suppresses duplication-mediated genome instability. Putnam CD, et al. PLoS Genet, 2010 May 6. PMID 20463880.
    5. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32923 BioGRID:31302 ADE16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32923 BioGRID:31652 ATP10    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35845 ATP23    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:32859 CDC28    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32923 BioGRID:34396 COQ10    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35772 COX5A    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:34464 CYT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:34046 CYT2    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:33335 DBF2    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:32418 ESC2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32923 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32923 BioGRID:34024 HAP4    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:34743 HAP5    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:32699 HTA2    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:34594 LIP5    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35747 MKS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:32892 MSI1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:36903 PET122    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31461 PEX13    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31994 PEX19    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:33483 PHB2    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35810 PUB1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32923 BioGRID:36153 RMI1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32923 BioGRID:36237 ROX1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:36588 RTT107    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:32923 BioGRID:32449 RVS167    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35368 SGS1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Lethality 
    BioGRID:32923 BioGRID:31404 SLX4    BioGRID  PubMed Affinity Capture-Western; Co-purification; Two-hybrid 
    BioGRID:32923 BioGRID:31642 SMC6    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:32561 SMT3    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31016 SNT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31391 SRN2    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31503 TOP3    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32923 BioGRID:36157 ULP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35831 VPS27    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:300455 YDL118W    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:31944 YDL119C    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:33003 YGL235W    BioGRID  PubMed Positive Genetic 
    BioGRID:32923 BioGRID:33611 YJL147C    BioGRID  PubMed Negative Genetic 
    BioGRID:32923 BioGRID:35281 YKU80    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32923 BioGRID:33519 YTA7    BioGRID  PubMed Negative Genetic 
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    General gene information

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    5'-flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-dependent DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Slx1-Slx4 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Slx1p
    NP_009787.1
    • Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8

      Range
      675313..676227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178576.1 → NP_009787.1  TPA: Slx1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P38324
      Conserved Domains (1) summary
      cd10455
      Location:13 – 87
      Blast Score: 335
      GIY-YIG_SLX1; Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006936.2 DAA07343.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P38324.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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