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HPC2 Hpc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852516, updated on 11-Apr-2024

Summary

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Gene symbol
HPC2
Gene description
Hpc2p
Primary source
SGD:S000000419
Locus tag
YBR215W
See related
AllianceGenome:SGD:S000000419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA binding activity and nucleosome binding activity. Involved in DNA replication-independent chromatin assembly; regulation of transcription involved in G1/S transition of mitotic cell cycle; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of HIR complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_001134.8 (653356..655317)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 Neighboring gene Sds24p Neighboring gene Ybp1p Neighboring gene Atg12p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Prochasson P, et al. Genes Dev, 2005 Nov 1. PMID 16264190, Free PMC Article
  2. Uncoupling histone turnover from transcription-associated histone H3 modifications. Ferrari P, et al. Nucleic Acids Res, 2015 Apr 30. PMID 25845593, Free PMC Article
  3. Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes. Vishnoi N, et al. Biochim Biophys Acta, 2011 Oct. PMID 21782987, Free PMC Article
  4. Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. Banumathy G, et al. Mol Cell Biol, 2009 Feb. PMID 19029251, Free PMC Article
  5. Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Xu H, et al. Mol Cell Biol, 1992 Nov. PMID 1406694, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The histone chaperone gene HPC2 reversed the elevated manganese and phosphate of pho80 mutants by specifically repressing PHO84, encoding a metal-phosphate transporter.
    Title: Phosphate disruption and metal toxicity in Saccharomyces cerevisiae: effects of RAD23 and the histone chaperone HPC2.
  2. the separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes
    Title: Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of HIR complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HIR complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Hpc2p
NP_009774.4
  • Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 Reference assembly

    Range
    653356..655317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178563.3 → NP_009774.4  TPA: Hpc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009774.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBP6, D6VQL1, Q01448
    UniProtKB/TrEMBL
    A6ZLF5
    Conserved Domains (1) summary
    pfam08729
    Location:558 → 601
    HUN; HPC2 and ubinuclein domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01448.2

Gene LinkOut

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