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DGKZ diacylglycerol kinase, zeta [ Homo sapiens (human) ]

Gene ID: 8525, updated on 7-Dec-2014
Official Symbol
DGKZprovided by HGNC
Official Full Name
diacylglycerol kinase, zetaprovided by HGNC
Primary source
HGNC:HGNC:2857
See related
Ensembl:ENSG00000149091; HPRD:03260; MIM:601441; Vega:OTTHUMG00000166437
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
See DGKZ in Epigenomics, MapViewer
Location:
11p11.2
Exon count:
35
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (46332905..46380554)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (46354455..46402104)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928919 Neighboring gene cAMP responsive element binding protein 3-like 1 Neighboring gene microRNA 4688 Neighboring gene cholinergic receptor, muscarinic 4 Neighboring gene midkine (neurite growth-promoting factor 2)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
cell migration NAS
Non-traceable Author Statement
more info
PubMed 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic G1 DNA damage checkpoint IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
diacylglycerol kinase zeta
Names
diacylglycerol kinase zeta
DAG kinase zeta
diglyceride kinase zeta
diacylglycerol kinase, zeta 104kDa
NP_001099010.1
NP_001186195.1
NP_001186196.1
NP_001186197.1
NP_003637.2
NP_963290.1
NP_963291.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105540.1NP_001099010.1  diacylglycerol kinase zeta isoform 4

    See proteins identical to NP_001099010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC116021, U94905
    Consensus CDS
    CCDS41640.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000412178, OTTHUMP00000232891, ENST00000454345, OTTHUMT00000389772
    Conserved Domains (6) summary
    smart00045
    Location:635792
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:486607
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:482805
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:361414
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:9831099
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9831077
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_001199266.1NP_001186195.1  diacylglycerol kinase zeta isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate 5' sequence including the coding region and extra nts CAG and an extra segment at alternate splice sites, respectively, in the CDS, compared to variant 4. The resulting isoform (5) has a shorter and distinct N-terminus, and an internal additional aa and an additional segment, compared to isoform 4.
    Source sequence(s)
    AK225774, CB959911, U51477
    Consensus CDS
    CCDS55757.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000436291, OTTHUMP00000233029, ENST00000527911, OTTHUMT00000389999
    Conserved Domains (6) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:173226
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:795916
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795894
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_001199267.1NP_001186196.1  diacylglycerol kinase zeta isoform 6

    See proteins identical to NP_001186196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate 5' sequence including the coding region compared to variant 4. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    CB959911, U51477
    Consensus CDS
    CCDS55759.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000395684, OTTHUMP00000238021, ENST00000456247, OTTHUMT00000398328
    Conserved Domains (6) summary
    smart00045
    Location:446603
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:297418
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:293616
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:172225
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:794910
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:794888
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001199268.1NP_001186197.1  diacylglycerol kinase zeta isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, and lacks an in-frame coding exon, compared to variant 4. The resulting isoform (7) has a shorter and distinct N-terminus and an internal additional aa, and lacks an internal segment, compared to isoform 4.
    Source sequence(s)
    AK294888, CB959911, U51477
    Consensus CDS
    CCDS55758.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000320340, OTTHUMP00000274878, ENST00000318201, OTTHUMT00000474167
    Conserved Domains (5) summary
    smart00045
    Location:424581
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:275396
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:271594
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00204
    Location:772888
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:772866
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_003646.3NP_003637.2  diacylglycerol kinase zeta isoform 2

    See proteins identical to NP_003637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus and an internal additional aa, compared to isoform 4.
    Source sequence(s)
    BU849628, CB959911, U94905
    Consensus CDS
    CCDS44580.1
    UniProtKB/Swiss-Prot
    Q13574
    Conserved Domains (6) summary
    smart00045
    Location:447604
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:298419
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:294617
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:173226
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:795911
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:795889
    Ank_2; Ankyrin repeats (3 copies)
  6. NM_201532.2NP_963290.1  diacylglycerol kinase zeta isoform 1

    See proteins identical to NP_963290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate 5' sequence including the coding region, compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 4.
    Source sequence(s)
    AK124594, U51477
    Consensus CDS
    CCDS7918.1
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000343065, OTTHUMP00000232889, ENST00000343674, OTTHUMT00000389770
    Conserved Domains (6) summary
    smart00045
    Location:463620
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:314435
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:310633
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:189242
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:811927
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:811905
    Ank_2; Ankyrin repeats (3 copies)
  7. NM_201533.3NP_963291.2  diacylglycerol kinase zeta isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' sequence including the coding region, lacks nts GAG at an alternate splice site and has extra nts CAG at another alternate splice sites in the CDS, compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus, lacks an internal aa in one region and has an additional aa in another region, compared to isoform 4.
    Source sequence(s)
    AK300577, DC416889, U51477
    Consensus CDS
    CCDS44579.2
    UniProtKB/Swiss-Prot
    Q13574
    Related
    ENSP00000436273, OTTHUMP00000233028, ENST00000532868, OTTHUMT00000389998
    Conserved Domains (6) summary
    smart00045
    Location:451608
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:302423
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:298621
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:177230
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:799915
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:799893
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    46332905..46380554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253181.2XP_005253238.1  

    Conserved Domains (6) summary
    smart00045
    Location:464621
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:315436
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:311634
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:190243
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:812928
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:812906
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_005253182.2XP_005253239.1  

    See proteins identical to XP_005253239.1

    Conserved Domains (6) summary
    smart00045
    Location:452609
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:303424
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:299622
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:178231
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:800916
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:800894
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_006718355.1XP_006718418.1  

    Conserved Domains (6) summary
    smart00045
    Location:451608
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:302423
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:298621
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:177230
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:799915
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:799893
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_006718354.1XP_006718417.1  

    Conserved Domains (6) summary
    smart00045
    Location:636793
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:487608
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:483806
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:362415
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:9841100
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:9841078
    Ank_2; Ankyrin repeats (3 copies)
  5. XM_005253179.2XP_005253236.1  

    Conserved Domains (6) summary
    smart00045
    Location:679836
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:530651
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:526849
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:405458
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:10271143
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10271121
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_005253180.2XP_005253237.1  

    Conserved Domains (6) summary
    smart00045
    Location:678835
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:529650
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:525848
    LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]
    cd00029
    Location:404457
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00204
    Location:10261142
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:10261120
    Ank_2; Ankyrin repeats (3 copies)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    46352750..46400540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    46061412..46109062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)