DGKZ diacylglycerol kinase, zeta [Homo sapiens (human)] - Gene

Summary

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Official Symbol: DGKZprovided by HGNC
Official Full Name: diacylglycerol kinase, zetaprovided by HGNC
Primary source: HGNC:2857
See related: Ensembl:ENSG00000149091; HPRD:03260; MIM:601441; Vega:OTTHUMG00000166437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAGK5; DAGK6; DGK-ZETA; hDGKzeta
Summary: The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]

Genomic context

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Location :: 11p11.2

Sequence :: Chromosome: 11; NC_000011.9 (46354455..46402104)

See DGKZ in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

DGK regulates melanogenesis via modulation of the posttranslational processing of tyrosinase, which may be related with the protein degradation machinery.
Title: Diacylglycerol kinase regulates tyrosinase expression and function in human melanocytes.
DGK-zeta translocated rapidly to the plasma membrane at early stages of immunological synapse (IS) formation independent of enzyme activity; study highlights a DGKzeta-specific function for local diacylglycerol metabolism at the IS and offers new clues to its mode of regulation
Title: Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.
Antigen-specific CD8-positive T cells from DGKzeta-deficient transgenic mice show enhanced expansion and increased cytokine production after lymphocytic choriomeningitis virus infection, yet DGK-deficient memory CD8+ T cells exhibit impaired expansion.
Title: Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases.
Nucleosome assembly protein (NAP) 1-like 1 (NAP1L1) and NAP1-like 4 (NAP1L4) are identified as novel DGKzeta binding partners.
Title: Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins.
Data show that Diacylglycerol that 2-arachidonoyl glycerol is a very poor substrate for either the epsilon or the zeta isoforms of diacylglycerol kinases.
Title: Endocannabinoids and diacylglycerol kinase activity.
None of SNPs of diacylglycerol kinase zeta tested showed association with bipolar disorder in Sardinian sample.
Title: The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample.
In DGKzeta-deficient fibroblasts PAK1 phosphorylation and Rac1-RhoGDI dissociation were attenuated, leading to reduced Rac1 activation after platelet-derived growth factor stimulation.
Title: Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
PKD activation is induced by DGKzeta, suggesting DGK is an upstream regulator of oxidative stress-induced activation of the PKD signaling pathway in intestinal epithelial cells.
Title: Diacylglycerol kinase regulation of protein kinase D during oxidative stress-induced intestinal cell injury.
2,3-dioleoylglycerol binds to a site on the alpha and zeta isoforms of diacylglycerol kinase that is exposed as a consequence of the substrate binding to the active site.
Title: Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
structural domain requirements for translocation and activity
Title: Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity.

Submit: New GeneRIF Correction See all (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13574	P11532	DMD	HPRD	PubMed
Q13574	P01112	HRAS	HPRD	PubMed
Q13574	P48357	LEPR	HPRD	PubMed
Q13574	P19174	PLCG1	HPRD	PubMed
Q13574	GRINL1A downstream protein Gdown1	POLR2M	HPRD	PubMed
Q13574	P17252	PRKCA	HPRD	PubMed
Q13574	RAS guanyl nucleotide releasing protein 1	RASGRP1	HPRD	PubMed
Q13574	P06400	RB1	HPRD	PubMed
Q13574	P28749	RBL1	HPRD	PubMed
Q13574	Q08999	RBL2	HPRD	PubMed
Q13574	P21673	SAT1	HPRD	PubMed
Q13574	Q13424	SNTA1	HPRD	PubMed
Q13574	Q13884	SNTB1	HPRD	PubMed
Q13574	Q13425	SNTB2	HPRD	PubMed
Q13574	Q9NSN8	SNTG1	HPRD	PubMed
Q13574	Q96L92	SNX27	HPRD	PubMed
Q13574	P12931	SRC	HPRD	PubMed
BioGRID:114095	BioGRID:106901	ARRB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114095	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114095	BioGRID:121487	CBX8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114095	BioGRID:199245	Dmd	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:109501	HRAS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:114095	BioGRID:119157	PARD6A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:111308	PIK3CA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114095	BioGRID:111351	PLCG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:123498	POLR2M	BioGRID	PubMed	Two-hybrid
BioGRID:114095	BioGRID:115429	RASGRP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:111868	RBL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:111869	RBL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114095	BioGRID:112210	SAT1	BioGRID	PubMed	Two-hybrid
BioGRID:114095	BioGRID:112523	SNTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114095	BioGRID:112524	SNTB1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114095	BioGRID:112528	SNTB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114095	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-Western; Co-localization

Pathways from BioSystems

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Effects of PIP2 hydrolysis, organism-specific biosystem (from REACTOME)
Effects of PIP2 hydrolysis, organism-specific biosystemHydrolysis of phosphatidyl inositol-bisphosphate (PIP2) by phospholipase C (PLC) produces diacylglycerol (DAG) and inositol triphosphate (IP3). Both are potent second messengers. IP3 diffuses into th...
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
Glycerolipid metabolism, organism-specific biosystem (from KEGG)
Glycerolipid metabolism, organism-specific biosystem
Glycerolipid metabolism
Glycerolipid metabolism, conserved biosystem (from KEGG)
Glycerolipid metabolism, conserved biosystem
Glycerolipid metabolism
Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
Glycerophospholipid metabolism, organism-specific biosystem
Glycerophospholipid metabolism
Glycerophospholipid metabolism, conserved biosystem (from KEGG)
Glycerophospholipid metabolism, conserved biosystem
Glycerophospholipid metabolism
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
Phosphatidylinositol signaling system, organism-specific biosystem
Phosphatidylinositol signaling system
Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
Phosphatidylinositol signaling system, conserved biosystem
Phosphatidylinositol signaling system
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

General gene information

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Markers

PMC20810P1 (e-PCR)
- UniSTS:271977

PMC20810P2 (e-PCR)
- UniSTS:271978

RH48086 (e-PCR)
- UniSTS:88700

DGKZ_1591 (e-PCR)
- UniSTS:277163

MARC_9821-9822:996688622:1 (e-PCR)
- UniSTS:270005

RH12588 (e-PCR)
- UniSTS:2807

Homology

Homologs of the DGKZ gene: The DGKZ gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
diacylglycerol kinase activity	IEA Inferred from Electronic Annotation more info
enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
lipid kinase activity	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
protein C-terminus binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
blood coagulation	TAS Traceable Author Statement more info
cell migration	NAS Non-traceable Author Statement more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
lipid phosphorylation	IDA Inferred from Direct Assay more info	PubMed
mitotic G1 DNA damage checkpoint	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
negative regulation of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
platelet activation	TAS Traceable Author Statement more info
protein kinase C-activating G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info
nucleus	IDA Inferred from Direct Assay more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: diacylglycerol kinase zeta

Names: diacylglycerol kinase zeta; DAG kinase zeta; diglyceride kinase zeta; diacylglycerol kinase, zeta 104kDa

NP_001099010.1

EC 2.7.1.107

NP_001186195.1

EC 2.7.1.107

NP_001186196.1

EC 2.7.1.107

NP_001186197.1

EC 2.7.1.107

NP_003637.2

EC 2.7.1.107

NP_963290.1

EC 2.7.1.107

NP_963291.2

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105540.1 → NP_001099010.1 diacylglycerol kinase zeta isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AC116021, U94905

Consensus CDS

CCDS41640.1

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000412178, OTTHUMP00000232891, ENST00000454345, OTTHUMT00000389772

Conserved Domains (6) summary

cd00029
Location:361 – 414
Blast Score: 92

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:983 – 1099
Blast Score: 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:482 – 805
Blast Score: 194

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:635 – 792
Blast Score: 628

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:486 – 607
Blast Score: 450

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:983 – 1077
Blast Score: 180

Ank_2; Ankyrin repeats (3 copies)
NM_001199266.1 → NP_001186195.1 diacylglycerol kinase zeta isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' sequence including the coding region and extra nts CAG and an extra segment at alternate splice sites, respectively, in the CDS, compared to variant 4. The resulting isoform (5) has a shorter and distinct N-terminus, and an internal additional aa and an additional segment, compared to isoform 4.

Source sequence(s)

AK225774, CB959911, U51477

Consensus CDS

CCDS55757.1

UniProtKB/TrEMBL

E9PPW4

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000436291, OTTHUMP00000233029, ENST00000527911, OTTHUMT00000389999

Conserved Domains (6) summary

cd00029
Location:173 – 226
Blast Score: 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:795 – 916
Blast Score: 201

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:294 – 617
Blast Score: 194

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:447 – 604
Blast Score: 626

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 – 419
Blast Score: 452

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:795 – 894
Blast Score: 166

Ank_2; Ankyrin repeats (3 copies)
NM_001199267.1 → NP_001186196.1 diacylglycerol kinase zeta isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' sequence including the coding region compared to variant 4. The resulting isoform (6) has a shorter and distinct N-terminus, compared to isoform 4.

Source sequence(s)

CB959911, U51477

Consensus CDS

CCDS55759.1

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000395684, OTTHUMP00000238021, ENST00000456247, OTTHUMT00000398328

Conserved Domains (6) summary

cd00029
Location:172 – 225
Blast Score: 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:794 – 910
Blast Score: 215

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:293 – 616
Blast Score: 193

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:446 – 603
Blast Score: 625

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:297 – 418
Blast Score: 452

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:794 – 888
Blast Score: 179

Ank_2; Ankyrin repeats (3 copies)
NM_001199268.1 → NP_001186197.1 diacylglycerol kinase zeta isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, and lacks an in-frame coding exon, compared to variant 4. The resulting isoform (7) has a shorter and distinct N-terminus and an internal additional aa, and lacks an internal segment, compared to isoform 4.

Source sequence(s)

AK294888, CB959911, U51477

Consensus CDS

CCDS55758.1

UniProtKB/TrEMBL

B7Z2M9

UniProtKB/TrEMBL

J3KNJ6

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000320340, ENST00000318201

Conserved Domains (5) summary

cd00204
Location:772 – 888
Blast Score: 216

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:271 – 594
Blast Score: 192

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:424 – 581
Blast Score: 627

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:275 – 396
Blast Score: 452

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:772 – 866
Blast Score: 179

Ank_2; Ankyrin repeats (3 copies)
NM_003646.3 → NP_003637.2 diacylglycerol kinase zeta isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate 5' sequence including the coding region and extra nts CAG at an alternate splice site in the CDS, compared to variant 4. The resulting isoform (2) has a shorter and distinct N-terminus and an internal additional aa, compared to isoform 4.

Source sequence(s)

BU849628, CB959911, U94905

Consensus CDS

CCDS44580.1

UniProtKB/Swiss-Prot

Q13574

Conserved Domains (6) summary

cd00029
Location:173 – 226
Blast Score: 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:795 – 911
Blast Score: 215

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:294 – 617
Blast Score: 194

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:447 – 604
Blast Score: 625

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:298 – 419
Blast Score: 452

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:795 – 889
Blast Score: 179

Ank_2; Ankyrin repeats (3 copies)
NM_201532.2 → NP_963290.1 diacylglycerol kinase zeta isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) has an alternate 5' sequence including the coding region, compared to variant 4. The resulting isoform (1) has a shorter and distinct N-terminus, compared to isoform 4.

Source sequence(s)

AK124594, U51477

Consensus CDS

CCDS7918.1

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000343065, OTTHUMP00000232889, ENST00000343674, OTTHUMT00000389770

Conserved Domains (6) summary

cd00029
Location:189 – 242
Blast Score: 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:811 – 927
Blast Score: 216

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:310 – 633
Blast Score: 195

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:463 – 620
Blast Score: 626

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:314 – 435
Blast Score: 453

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:811 – 905
Blast Score: 179

Ank_2; Ankyrin repeats (3 copies)
NM_201533.3 → NP_963291.2 diacylglycerol kinase zeta isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' sequence including the coding region, lacks nts GAG at an alternate splice site and has extra nts CAG at another alternate splice sites in the CDS, compared to variant 4. The resulting isoform (3) has a shorter and distinct N-terminus, lacks an internal aa in one region and has an additional aa in another region, compared to isoform 4.

Source sequence(s)

AK300577, DC416889, U51477

Consensus CDS

CCDS44579.1

UniProtKB/TrEMBL

B7Z6M3

UniProtKB/Swiss-Prot

Q13574

Related

ENSP00000436273, OTTHUMP00000233028, ENST00000532868, OTTHUMT00000389998

Conserved Domains (6) summary

cd00029
Location:177 – 230
Blast Score: 91

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00204
Location:799 – 915
Blast Score: 216

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

COG1597
Location:298 – 621
Blast Score: 196

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

smart00045
Location:451 – 608
Blast Score: 626

DAGKa; Diacylglycerol kinase accessory domain (presumed)

smart00046
Location:302 – 423
Blast Score: 453

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

pfam12796
Location:799 – 893
Blast Score: 180

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

46354455..46402104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

46061412..46109062

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

46280239..46327956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01060748.1 (11214..58864)	None
genomic	AC116021.5 (99699..147064)	None
genomic	AMYH01003533.1 (170879..205551)	None
genomic	AMYH01003534.1	None
genomic	CH471064.2	EAW68006.1
		EAW68007.1
		EAW68008.1
		EAW68009.1
mRNA	AB209635.1	BAD92872.1
mRNA	AK097960.1	None
mRNA	AK123378.1	BAC85599.1
mRNA	AK124594.1	BAC85894.1
mRNA	AK124693.1	None
mRNA	AK126970.1	BAC86770.1
mRNA	AK225774.1	None
mRNA	AK293615.1	BAH11548.1
mRNA	AK294888.1	BAH11915.1
mRNA	AK300577.1	BAH13309.1
mRNA	AK303322.1	BAH13942.1
mRNA	AK312398.1	None
mRNA	BC008018.1	AAH08018.1
mRNA	BC041770.1	AAH41770.1
mRNA	BU849628.1	None
mRNA	BX370257.2	None
mRNA	BX648433.1	None
mRNA	BX649190.1	CAE46208.1
mRNA	CB959911.1	None
mRNA	DC416889.1	None
mRNA	U51477.1	AAC50478.1
mRNA	U94905.1	AAB60859.1