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    YSA1 Ysa1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852408, updated on 31-Jan-2012
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    Summary

    Gene symbol
    YSA1
    Gene description
    Ysa1p
    Primary source
    SGD:S000000315
    Locus tag
    YBR111C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RMA2
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    Genomic context

    Sequence :
    Chromosome: II; NC_001134.8 (461178..461873, complement)
    See YSA1 in MapViewer

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Cmd1p Neighboring gene Alg1p Neighboring gene Sus1p Neighboring gene Cyc8p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Characterization of cell cycle specific protein interaction networks of the yeast 26S proteasome complex by the QTAX strategy. Kaake RM, et al. J Proteome Res, 2010 Apr 5. PMID 20170199.
    3. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.
    4. Purification of nuclear poly(A)-binding protein Nab2 reveals association with the yeast transcriptome and a messenger ribonucleoprotein core structure. Batisse J, et al. J Biol Chem, 2009 Dec 11. PMID 19840948.
    5. Hydrolase regulates NAD+ metabolites and modulates cellular redox. Tong L, et al. J Biol Chem, 2009 Apr 24. PMID 19251690.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the Nudix (nucleoside diphosphate linked to another moiety X) hydrolase Ysa1 from Saccharomyces cerevisiae is a major regulator of cellular ADPr and O-acetyl-ADP-ribose (OAADPr)
      Title: Hydrolase regulates NAD+ metabolites and modulates cellular redox.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32815 BioGRID:35617 ALG9    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36693 ANP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31509 ARV1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33135 CDC20    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32815 BioGRID:31512 CDD1    BioGRID  PubMed Two-hybrid 
    BioGRID:32815 BioGRID:33227 CKB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31105 FET5    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35487 GAS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31884 GCS1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32815 BioGRID:34600 GEP3    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36828 GET2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35204 HOF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32815 BioGRID:34293 INO4    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34321 IRA2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36028 KIP2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36109 MUK1    BioGRID  PubMed Two-hybrid 
    BioGRID:32815 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32815 BioGRID:36171 NCR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33290 NQM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33829 OPI3    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31612 ORM2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:32589 PAU10    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:32329 PMP3    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33090 RAD54    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31315 RIC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36679 RML2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32815 BioGRID:33953 SAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:32210 SAC3    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35451 SCS7    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35255 SEC14    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32815 BioGRID:34644 SEC63    BioGRID  PubMed Positive Genetic 
    BioGRID:32815 BioGRID:35603 SIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33304 SPR3    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34398 TOP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33823 TOR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:33595 TPK1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34467 VAM10    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35928 VMA11    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34016 VPH2    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34133 VPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:36439 VPS29    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31363 XDJ1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35759 YDJ1    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35008 YIR016W    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31257 YLL058W    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31421 YLR152C    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:34621 YOR228C    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:31529 YPT6    BioGRID  PubMed Negative Genetic 
    BioGRID:32815 BioGRID:35264 YTA12    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ADP-ribose diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ADP-ribose diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ribose phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Ysa1p
    NP_009669.1
    • Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8

      Range
      461178..461873, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178459.1 → NP_009669.1  TPA: Ysa1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q01976
      Conserved Domains (1) summary
      cd03424
      Location:78 – 213
      Blast Score: 280
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006936.2 DAA07230.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q01976.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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