HIST1H2AH histone cluster 1, H2ah [Homo sapiens] - Gene

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Summary

Official Symbol: HIST1H2AHprovided by HGNC
Official Full Name: histone cluster 1, H2ahprovided by HGNC
Primary source: HGNC:13671
See related: Ensembl:ENSG00000184825; HPRD:13655; Vega:OTTHUMG00000014468
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: H2A/S; H2AFALii; dJ86C11.1; MGC171151
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 6p21.33

Sequence :: Chromosome: 6; NC_000006.11 (27114908..27115346)

See HIST1H2AH in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Protein phosphatase 2C gamma binds to/dephosphorylates H2A to affect chromatin function.
Title: A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:124438	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS
BioGRID:124438	BioGRID:1205541	tat		BioGRID	PubMed	Protein-peptide

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
nucleosome	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: histone H2A type 1-H

Names: histone H2A type 1-H; histone H2A/s; H2A histone family member

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080596.1 → NP_542163.1 histone H2A type 1-H

Status: REVIEWED

Source sequence(s)

AL021807

Consensus CDS

CCDS4622.1

UniProtKB/TrEMBL

A3KPC7

UniProtKB/Swiss-Prot

Q96KK5

Related

ENSP00000366679, OTTHUMP00000016173, ENST00000377459, OTTHUMT00000040136

Conserved Domains (1) summary

cd00074
Location:24 – 120
Blast Score: 418

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

27114908..27115346

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

26922971..26923409

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL021807.2	CAA16944.1
genomic	AY131988.1	AAN59969.1
genomic	CH471081.1	EAX03087.1
mRNA	AK312232.1	BAG35165.1
mRNA	BC093849.1	AAH93849.1
mRNA	BC093851.1	AAH93851.1
mRNA	BC134366.1	AAI34367.1
mRNA	BC148293.2	AAI48294.1
other-genetic	BC141469.1	AAI41470.1