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    PAC11 Pac11p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852099, updated on 6-May-2012
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    Summary

    Gene symbol
    PAC11
    Gene description
    Pac11p
    Primary source
    SGD:S000002896
    Locus tag
    YDR488C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: IV
    Sequence :
    Chromosome: IV; NC_001136.10 (1429188..1430789, complement)
    See PAC11 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps60p Neighboring gene Rib3p Neighboring gene Sld5p Neighboring gene Pkh1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning. Tang X, et al. J Cell Biol, 2012 Mar 19. PMID 22431751.
    2. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    3. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    4. Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Stuchell-Brereton MD, et al. Mol Biol Cell, 2011 Aug 1. PMID 21633107.
    5. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. IC/Pac11 has a essential role in dynein function which providing new insight into the offloading model.
      Title: The offloading model for dynein function: differential function of motor subunits.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32540 BioGRID:35686 AAH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32931 ABD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31107 ACT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35869 AGA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35988 APL5    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36562 ARP1    BioGRID  PubMed Two-hybrid 
    BioGRID:32540 BioGRID:34456 ASE1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:33639 ASF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36357 ATG13    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:35845 ATP23    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31136 AUA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35415 BCH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36905 BEM2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33807 BFA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36749 BIM1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Lethality 
    BioGRID:32540 BioGRID:35884 BIO3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32540 BioGRID:31501 BNA5    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:35569 BNI1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:36859 BOI2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32540 BioGRID:31535 BOP2    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:35876 BRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36231 BRR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35231 BUB2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34125 CAP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32832 CCZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35376 CIK1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34734 CIN1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32540 BioGRID:35922 CIN2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36668 CIN8    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:35540 CLA4    BioGRID  PubMed Dosage Growth Defect; Negative Genetic 
    BioGRID:32540 BioGRID:31478 CLB4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32540 BioGRID:32813 CMD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31654 COX8    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31484 CPR6    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31058 CSM1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32540 BioGRID:31640 CTF3    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:36302 CTF4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32540 BioGRID:35092 CTK3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33335 DBF2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34432 DFG16    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31273 DNM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35824 DOM34    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33186 DUO1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32483 DYN2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:32540 BioGRID:35700 FAR11    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35201 FAR8    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34927 FIS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31322 FRE8    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34578 FYV12    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31159 GCN20    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31779 GEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35676 GIM3    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32540 BioGRID:36728 GIM4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32540 BioGRID:35049 GIM5    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32540 BioGRID:34442 GLO4    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36333 GPH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31041 HCM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32540 BioGRID:35909 HFI1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35204 HOF1    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:31475 HRD3    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:35980 HRR25    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34392 HTZ1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33874 ILM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32179 INO2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31368 IOC2    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:31258 JLP1    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:35474 JNM1    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:36310 KAR3    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:35944 KAR9    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32540 BioGRID:30960 KCC4    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33080 KEM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36038 KES1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33041 KIP3    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:33827 LIA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34594 LIP5    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:31697 LSM3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35681 LSM7    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31742 LTE1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34395 MDM12    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34543 MDM32    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33644 MDV1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34606 MGM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31584 MMS22    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33127 MON1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35402 MRE11    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36585 MTC6    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34711 MYO2    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:36009 NIP100    BioGRID  PubMed Two-hybrid 
    BioGRID:32540 BioGRID:32203 NUM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:32540 BioGRID:33364 NUP57    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36393 OCA5    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33320 PAC10    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:31052 PAT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33582 PFD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36147 PHO85    BioGRID  PubMed Dosage Lethality 
    BioGRID:32540 BioGRID:35036 PML39    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36745 PRP22    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32635 PRX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32540 BioGRID:33678 PRY3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31635 PSY3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31306 RAD5    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33806 RAD7    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34664 RIM20    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36237 ROX1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35678 RPC31    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31663 RPL31B    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34225 RPL40B    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31921 RPO21    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36817 RPS24A    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34577 RPS30B    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32879 RPS6B    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35202 RSF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33708 RTT101    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31249 RTT109    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:30988 RVS161    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33953 SAC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32210 SAC3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36865 SCS2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33591 SET2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32807 SIF2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33481 SMI1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32529 SNF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31391 SRN2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32345 SSD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31518 SSP120    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:32663 STU1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:31320 STU2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36318 SUE1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36987 SUS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34574 SYC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36052 TAF14    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31616 TAL1    BioGRID  PubMed Positive Genetic 
    BioGRID:32540 BioGRID:36601 THP2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35744 TPM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35401 UBP8    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36844 UBP9    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31463 UPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34502 VAM3    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31984 VAM6    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31633 VID22    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34133 VPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36439 VPS29    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31621 VPS38    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31363 XDJ1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:32428 XRS2    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35717 YAF9    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31469 YKE2    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32540 BioGRID:34063 YKL069W    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31316 YLR040C    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31394 YLR125W    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31412 YLR143W    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:31508 YLR241W    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:33531 YOR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:36249 YPR078C    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:35170 YPT7    BioGRID  PubMed Negative Genetic 
    BioGRID:32540 BioGRID:34566 YRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32540 BioGRID:57920 ctp    BioGRID  PubMed Co-fractionation; Reconstituted Complex 
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    General gene information

    Homology

    Pathways from BioSystems

    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to plus-end-directed microtubule motor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    microtubule-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    nuclear migration along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic dynein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytoplasmic microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic microtubule IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Pac11p
    NP_010776.1
    • Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      1429188..1430789, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180796.1 → NP_010776.1  Pac11p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P40960
      Conserved Domains (1) summary
      cl02567
      Location:431 – 466
      Blast Score: 86
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA12321.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40960.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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