Display Settings:

Format

Send to:

Choose Destination

TSA2 thioredoxin peroxidase TSA2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 852064, updated on 16-Jan-2015
Gene symbol
TSA2
Gene description
thioredoxin peroxidase TSA2
Primary source
SGD:S000002861
Locus tag
YDR453C
Gene type
protein coding
RNA name
thioredoxin peroxidase TSA2
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See TSA2 in MapViewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1365072..1365662, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Yhp1p Neighboring gene Ppn1p Neighboring gene guanylate kinase Neighboring gene bifunctional K:H/Na:H antiporter NHX1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxiredoxin activity IDA
Inferred from Direct Assay
more info
PubMed 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
thioredoxin peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Names
thioredoxin peroxidase TSA2
NP_010741.1
  • Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 

    Range
    1365072..1365662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180761.1NP_010741.1  thioredoxin peroxidase TSA2 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_010741.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q04120
    Conserved Domains (2) summary
    COG0450
    Location:1192
    AhpC; Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]
    cd03015
    Location:5176
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...