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ADA2 Ada2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 852059, updated on 6-Jul-2014
Gene symbol
ADA2
Gene description
Ada2p
Primary source
SGD:S000002856
Locus tag
YDR448W
Gene type
protein coding
RNA name
Ada2p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SWI8
See ADA2 in MapViewer
Location:
chromosome: IV
Exon count :
1
Sequence:
Chromosome: IV; NC_001136.10 (1356065..1357369)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ecm11p Neighboring gene ribosomal 40S subunit protein S17B Neighboring gene Utp6p Neighboring gene ribosomal 40S subunit protein S18A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin modification IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing at rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
Ada2p
NP_010736.3
  • Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 

    Range
    1356065..1357369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180756.3NP_010736.3  Ada2p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_010736.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q02336
    Conserved Domains (4) summary
    COG5114
    Location:3434
    Blast Score: 1905
    COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    cd00167
    Location:65107
    Blast Score: 118
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The ...
    cd02335
    Location:553
    Blast Score: 227
    ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam04433
    Location:355428
    Blast Score: 145
    SWIRM; SWIRM domain

Supplemental Content

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