HAT1 histone acetyltransferase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: HAT1provided by HGNC
Official Full Name: histone acetyltransferase 1provided by HGNC
Primary source: HGNC:4821
See related: Ensembl:ENSG00000128708; HPRD:04339; MIM:603053; Vega:OTTHUMG00000132282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KAT1
Summary: The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]

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Genomic context

Location :: 2q31.2-q33.1

Sequence :: Chromosome: 2; NC_000002.11 (172778935..172848600)

See HAT1 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HAT1 differentially impacts nucleosome assembly of H3.1-H4 and H3.3-H4.
Title: Human histone acetyltransferase 1 protein preferentially acetylates H4 histone molecules in H3.1-H4 over H3.3-H4.
HAT gene expression is required for cisplatin resistance and Clock and Tip60 regulate not only transcription, but also DNA repair, through periodic histone acetylation
Title: Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.
the role of Hat1 in DNA damage repair is evolutionarily conserved, the ability of H3 acetylation to compensate for Hat1 deletion appears to be more variable
Title: Properties of the type B histone acetyltransferase Hat1: H4 tail interaction, site preference, and involvement in DNA repair.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
O14929	O15105	SMAD7	HPRD	PubMed
BioGRID:114092	BioGRID:120845	ASF1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:123745	ATG10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113911	BAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:115448	G3BP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:109268	H2AFX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114092	BioGRID:109272	H3F3A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113946	HIST1H3A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113949	HIST1H3E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113955	HIST1H4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113895	HIST3H3	BioGRID	PubMed	Affinity Capture-MS; Co-purification
BioGRID:114092	BioGRID:125732	HIST4H4	BioGRID	PubMed	Biochemical Activity
BioGRID:114092	BioGRID:122828	IPO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:111866	RBBP7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114092	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transferase activity, transferring acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA packaging	TAS Traceable Author Statement more info	PubMed
chromatin modification	IEA Inferred from Electronic Annotation more info
chromatin silencing at telomere	IEA Inferred from Electronic Annotation more info
histone acetylation	TAS Traceable Author Statement more info	PubMed
internal protein amino acid acetylation	TAS Traceable Author Statement more info	PubMed
response to nutrient	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
nuclear matrix	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: histone acetyltransferase type B catalytic subunit

Names: histone acetyltransferase type B catalytic subunit

NP_003633.1

EC 2.3.1.48

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003642.3 → NP_003633.1 histone acetyltransferase type B catalytic subunit

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AF030424, BG184638, DB050336

Consensus CDS

CCDS2245.1

UniProtKB/Swiss-Prot

O14929

Related

ENSP00000264108, OTTHUMP00000163124, ENST00000264108, OTTHUMT00000255377

Conserved Domains (1) summary

pfam10394
Location:26 – 187
Blast Score: 503

Hat1_N; Histone acetyl transferase HAT1 N-terminus

RNA

NR_027862.1 RNA Sequence

Description

Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BC063003, DB050336

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

172778935..172848600

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

164663728..164732503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001033085.1: Suppressed sequence

Description

NM_001033085.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC015976.8	AAY14731.1
genomic	AC114745.6	AAX93247.1
genomic	CH471058.2	EAX11194.1
		EAX11195.1
mRNA	AF030424.1	AAC02425.1
mRNA	AK127840.1	None
mRNA	AK309001.1	None
mRNA	AK313699.1	None
mRNA	BC018682.1	AAH18682.1
mRNA	BC045673.1	None
mRNA	BC063003.1	AAH63003.1
mRNA	BG184638.1	None
mRNA	DB050336.1	None
other-genetic	HQ448051.1	ADQ32532.1