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    SAC7 Sac7p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851997, updated on 8-Jan-2012
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    Summary

    Gene symbol
    SAC7
    Gene description
    Sac7p
    Primary source
    SGD:S000002797
    Locus tag
    YDR389W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: IV; NC_001136.10 (1252537..1254501)
    See SAC7 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Rvs167p Neighboring gene Uba2p Neighboring gene tRNA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Sites of ubiquitin attachment in Saccharomyces cerevisiae. Starita LM, et al. Proteomics, 2012 Jan. PMID 22106047.
    2. A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression. Zimmermann C, et al. Proc Natl Acad Sci U S A, 2011 Nov 15. PMID 22042866.
    3. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    4. Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Echtenkamp FJ, et al. Mol Cell, 2011 Jul 22. PMID 21777812.
    5. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. León Ortiz AM, et al. DNA Repair (Amst), 2011 May 5. PMID 21459050.

    See all (44) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32450 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Haploinsufficiency; Synthetic Lethality; Synthetic Rescue 
    BioGRID:32450 BioGRID:33177 AFT1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35958 ALG5    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:31362 ALT1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:32027 ARP2    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32450 BioGRID:33675 ARP4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:31509 ARV1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34530 BAG7    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:34957 BCY1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:36905 BEM2    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:36749 BIM1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:35876 BRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35668 CBK1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35210 CCS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:31825 CDC13    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:36600 CDC23    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:31724 CDC24    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:32859 CDC28    BioGRID  PubMed Biochemical Activity; Synthetic Growth Defect 
    BioGRID:32450 BioGRID:32107 CDC34    BioGRID  PubMed Dosage Lethality; Synthetic Growth Defect 
    BioGRID:32450 BioGRID:32219 CDC37    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:31930 CDC53    BioGRID  PubMed Dosage Lethality; Synthetic Growth Defect 
    BioGRID:32450 BioGRID:32813 CMD1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:35773 COG5    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36302 CTF4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:30996 CWH43    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:31622 DCR2    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:31753 DEP1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:34479 DIA2    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32450 BioGRID:34085 ELM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36084 ERI1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35075 ERO1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34635 ESA1    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32450 BioGRID:31717 GAB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35487 GAS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33226 GET1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:36828 GET2    BioGRID  PubMed Phenotypic Suppression; Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35049 GIM5    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:33666 GWT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33594 HAL5    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:35364 HSC82    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:33933 HYM1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:33874 ILM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34990 INP51    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35718 INP52    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:34505 INP53    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:33845 JSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:32450 BioGRID:33726 KAR2    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:35944 KAR9    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:36038 KES1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35601 KEX2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32450 BioGRID:34626 KIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35518 KRE1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32450 BioGRID:34719 KRE5    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35517 LEM3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:36125 LGE1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:31595 MID2    BioGRID  PubMed Dosage Lethality; Positive Genetic; Synthetic Rescue 
    BioGRID:32450 BioGRID:32213 NBP2    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33829 OPI3    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34500 OST2    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34483 OST3    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:31052 PAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:32450 BioGRID:35080 PGA3    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33328 PIL1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:32598 PKC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33087 PMR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34217 PRP16    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36745 PRP22    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:35659 PSD1    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:32048 PTC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34021 RAD27    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:36030 RAD53    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:32191 RGP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36338 RHO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:32450 BioGRID:31315 RIC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36395 RIM101    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:33313 ROM1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:31631 ROM2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:35378 ROT1    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:32924 ROT2    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:36634 RPN10    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:34611 RUD3    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:34018 SBA1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32450 BioGRID:31536 SEC22    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:34916 SEC28    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:31638 SEC61    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:32871 SEC66    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:34437 SHE4    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:36640 SKN7    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:32692 SLA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34886 SLM1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:35777 SLM2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:36861 SLX8    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:31186 SMC2    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32450 BioGRID:33316 SMD1    BioGRID  PubMed Two-hybrid 
    BioGRID:32450 BioGRID:33665 SRS2    BioGRID  PubMed Dosage Lethality 
    BioGRID:32450 BioGRID:34959 SSM4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:31320 STU2    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:31632 SUR4    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33246 SWC4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:33753 SYS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34385 TLG2    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement 
    BioGRID:32450 BioGRID:33920 TOR2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:36838 TSC11    BioGRID  PubMed Phenotypic Suppression; Positive Genetic; Synthetic Rescue 
    BioGRID:32450 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32450 BioGRID:36901 UBP3    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35156 UBX2    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34467 VAM10    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:33348 VMA21    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:36702 VMA3    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:33349 VOA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:34133 VPS1    BioGRID  PubMed Negative Genetic; Phenotypic Suppression 
    BioGRID:32450 BioGRID:36114 VPS28    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34152 VPS51    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:36729 WBP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35636 WHI3    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:31539 YCS4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:36889 YER140W    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32450 BioGRID:31562 YHC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:35008 YIR016W    BioGRID  PubMed Positive Genetic 
    BioGRID:32450 BioGRID:31274 YLR001C    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:33866 YMR1    BioGRID  PubMed Dosage Rescue 
    BioGRID:32450 BioGRID:36525 YNG2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32450 BioGRID:35651 YNL181W    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34010 YPK1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32450 BioGRID:33618 YUR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32450 BioGRID:34291 ZEO1    BioGRID  PubMed Synthetic Lethality 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Rho GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    actin filament reorganization involved in cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Names
    Sac7p
    NP_010677.1
    • GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      1252537..1254501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180697.1 → NP_010677.1  Sac7p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P17121
      Conserved Domains (1) summary
      cd04396
      Location:122 – 393
      Blast Score: 816
      RhoGAP_fSAC7_BAG7; RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA12233.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P17121.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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