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    ESC2 Esc2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851965, updated on 5-Feb-2012
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    Summary

    Gene symbol
    ESC2
    Gene description
    Esc2p
    Primary source
    SGD:S000002771
    Locus tag
    YDR363W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Sequence :
    Chromosome: IV; NC_001136.10 (1199183..1200553)
    See ESC2 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Bcp1p Neighboring gene Tfc6p Neighboring gene tRNA Neighboring gene Sem1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome. Yu Z, et al. Mol Biol Cell, 2011 Apr. PMID 21289098.
    2. The Saccharomyces cerevisiae RAD9, RAD17 and RAD24 genes are required for suppression of mutagenic post-replicative repair during chronic DNA damage. Murakami-Sekimata A, et al. DNA Repair (Amst), 2010 Jul 1. PMID 20472512.
    3. The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Choi K, et al. Mol Biol Cell, 2010 Jul 1. PMID 20444977.
    4. Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing. Mimura S, et al. J Biol Chem, 2010 Mar 26. PMID 20139071.
    5. The genetic landscape of a cell. Costanzo M, et al. Science, 2010 Jan 22. PMID 20093466.

    See all (27) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that the Smc5/6 complex and Esc2 prevent the accumulation of toxic recombination intermediates generated in replication-associated recombinational repair.
      Title: The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae.
    2. Results identify a putative SUMO-binding motif in Esc2 that is necessary and sufficient for interacting with Sir2p and SUMO and is required for the function of Esc2p in transcriptional silencing.
      Title: Saccharomyces cerevisiae Esc2p interacts with Sir2p through a small ubiquitin-like modifier (SUMO)-binding motif and regulates transcriptionally silent chromatin in a locus-dependent manner.
    3. Esc2 and Smc5-6 act in concert with Sgs1 to prevent the accumulation of recombinogenic structures at damaged replication forks, likely by integrating sumoylation activities to regulate the repair pathways in response to damaged DNA
      Title: The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair.
    4. In the absence of both Esc2 and Sgs1, the intra-S-phase DNA damage checkpoint response is compromised after exposure to MMS
      Title: Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.
    5. Esc2 is functionally equivalent to a stable SUMO fusion protein and plays important roles in facilitating DNA replication fork progression and sister chromatid cohesion
      Title: A SUMO-like domain protein, Esc2, is required for genome integrity and sister chromatid cohesion in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32418 BioGRID:36693 ANP1    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:34535 ARP8    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:33340 ASK10    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:34957 BCY1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:32219 CDC37    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:31937 CDC48    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:32038 CDC7    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32106 DBF4    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:36548 DMA1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:33952 DOA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:32496 DOT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36712 EAF5    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35690 EAF7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:33556 ECM25    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34541 ELG1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:31122 EPL1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:35397 ESC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:33896 HIR3    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32775 HSP26    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34333 HST1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:35718 INP52    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:31947 IWR1    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:35476 LCB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34518 LEO1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:33632 LSM1    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:34842 MCM10    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35618 MGS1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:36337 MMS1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:32418 BioGRID:33163 MMS2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32418 BioGRID:36711 MMS21    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:32804 MMS4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:34993 MPH1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32418 BioGRID:30926 MRC1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32418 BioGRID:35077 MSC1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32447 MUS81    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:35256 NAM7    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:34552 NFI1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:36511 NMD2    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:34213 NUP133    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:31790 NUP60    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31946 NUP84    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:32800 PBY1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:35097 POB3    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:33794 POL32    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32130 PPH3    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35000 PRI1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36350 PRP4    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34634 PUS7    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:36692 RAD23    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34021 RAD27    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31306 RAD5    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:35589 RAD50    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32270 RAD9    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32418 BioGRID:32776 RDH54    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:36153 RMI1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:35751 RNH201    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32332 RNH202    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31423 RNH203    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32100 RPC11    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36101 RPL21B    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:34938 RPL34B    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32035 RPN4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31914 RPN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32418 BioGRID:36462 RRM3    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:33708 RTT101    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32418 BioGRID:36588 RTT107    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35235 SAM37    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35368 SGS1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:36420 SHU1    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32418 BioGRID:34232 SIR1    BioGRID  PubMed Dosage Rescue 
    BioGRID:32418 BioGRID:32017 SIR2    BioGRID  PubMed Phenotypic Enhancement; Two-hybrid 
    BioGRID:32418 BioGRID:32469 SIZ1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:34475 SKI7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:32923 SLX1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31404 SLX4    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:32041 SLX5    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:36861 SLX8    BioGRID  PubMed Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:31642 SMC6    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32561 SMT3    BioGRID  PubMed Two-hybrid 
    BioGRID:32418 BioGRID:36299 SPN1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36473 SRB2    BioGRID  PubMed Positive Genetic 
    BioGRID:32418 BioGRID:35136 SRC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:30946 SRO9    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:33665 SRS2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32418 BioGRID:36123 SUR1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:31792 SWD1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:33585 SWI3    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:32391 SWR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:35045 TAF13    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36601 THP2    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:34398 TOP1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:32786 UBC4    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:31995 UBC9    BioGRID  PubMed Two-hybrid 
    BioGRID:32418 BioGRID:32761 UBP14    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:31160 UBP6    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32418 BioGRID:35242 UBX4    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:33295 UFD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36157 ULP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34586 ULS1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32418 BioGRID:32257 UME6    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:33315 UPF3    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:31633 VID22    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:36567 WSS1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32418 BioGRID:33314 YGR071C    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32418 BioGRID:33611 YJL147C    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:34063 YKL069W    BioGRID  PubMed Negative Genetic 
    BioGRID:32418 BioGRID:36525 YNG2    BioGRID  PubMed Synthetic Growth Defect 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    chromatin silencing at silent mating-type cassette IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    double-strand break repair via homologous recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    intra-S DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    intra-S DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Esc2p
    NP_010650.1
    • Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      1199183..1200553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180671.1 → NP_010650.1  Esc2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q06340
      Conserved Domains (1) summary
      cl00155
      Location:384 – 443
      Blast Score: 172
      UBQ; Ubiquitin-like proteins
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA12201.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q06340.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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