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    MTH1 Mth1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851870, updated on 8-Jan-2012
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    Summary

    Gene symbol
    MTH1
    Gene description
    Mth1p
    Primary source
    SGD:S000002685
    Locus tag
    YDR277C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BPC1; DGT1; HTR1
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    Genomic context

    Sequence :
    Chromosome: IV; NC_001136.10 (1014401..1015702, complement)
    See MTH1 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Bsc2p Neighboring gene Pmp3p Neighboring gene tRNA Neighboring gene Rnh202p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. Hoppins S, et al. J Cell Biol, 2011 Oct 17. PMID 21987634.
    2. Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Boettner DR, et al. Mol Biol Cell, 2011 Oct. PMID 21849475.
    3. Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. Kvitek DJ, et al. PLoS Genet, 2011 Apr. PMID 21552329.
    4. Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, et al. Science, 2010 Dec 3. PMID 21127252.
    5. Epistatic relationships reveal the functional organization of yeast transcription factors. Zheng J, et al. Mol Syst Biol, 2010 Oct 5. PMID 20959818.

    See all (32) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MTH1 coding sequence has a large capacity for nonsense mutations.
      Title: Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape.
    2. Deletion of the MTH1 gene increased cell growth compared with the wild-type when cells were grown in a medium containing galactose and with hygromycin in yeast cells.
      Title: Saccharomyces cerevisiae glucose signalling regulator Mth1p regulates the organellar Na+/H+ exchanger Nhx1p.
    3. Mth1 is the primary regulator; Std1 serves to buffer the response to glucose.
      Title: Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae.
    4. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
      Title: Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_010563.1 NP_010143.1 RGT2    BIND  PubMed Rgt2 interacts with Mth1 as part of the glucose sensing signal. 
    BioGRID:32330 BioGRID:31060 ABP1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:30959 AGP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:35617 ALG9    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:33738 BBC1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:32897 BEM1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:32619 BOI1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:31798 BUD14    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:36547 BZZ1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:35459 CAT8    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:33419 CLC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:35092 CTK3    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:34893 FMC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:31125 GAT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:31962 GET3    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:32023 GPR1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32330 BioGRID:33844 GRR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32330 BioGRID:35473 HER2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:35364 HSC82    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32330 BioGRID:36423 HSE1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:35923 HSP82    BioGRID  PubMed Synthetic Growth Defect; Two-hybrid 
    BioGRID:32330 BioGRID:36528 HXT1    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:35180 HXT2    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:32401 HXT3    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:36527 HXT4    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:33776 LSM8    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:35750 MSK1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:31955 MSS2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:34006 MYO3    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:35285 MYO5    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32330 BioGRID:32213 NBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:32510 NHX1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:32330 BioGRID:33102 NUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:31461 PEX13    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:32953 POP4    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:36350 PRP4    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:33185 PYC1    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:32915 PYC2    BioGRID  PubMed Dosage Rescue 
    BioGRID:32330 BioGRID:34614 RCN2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:34094 RGT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:32330 BioGRID:31923 RGT2    BioGRID  PubMed Synthetic Rescue; Two-hybrid 
    BioGRID:32330 BioGRID:32692 SLA1    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:31851 SNF3    BioGRID  PubMed Synthetic Rescue; Two-hybrid 
    BioGRID:32330 BioGRID:32454 SPT3    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:36611 STB5    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:34448 STD1    BioGRID  PubMed Negative Genetic; Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:32330 BioGRID:36433 STP2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:32363 SUM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:32267 UPC2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:35609 URE2    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:32298 VHS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:31859 VMA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:31705 VMA6    BioGRID  PubMed Two-hybrid 
    BioGRID:32330 BioGRID:36439 VPS29    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:32136 VPS41    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:36672 YEL057C    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:33378 YGR130C    BioGRID  PubMed Negative Genetic 
    BioGRID:32330 BioGRID:35949 YPL264C    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    glucose transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Names
    Mth1p
    NP_010563.1
    • Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      1014401..1015702, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180585.1 → NP_010563.1  Mth1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P35198
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA12118.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P35198.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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