Display Settings:

Format

Send to:

Choose Destination

HEL2 Hel2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 851859, updated on 6-Jul-2014
Gene symbol
HEL2
Gene description
Hel2p
Primary source
SGD:S000002674
Locus tag
YDR266C
Gene type
protein coding
RNA name
Hel2p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See HEL2 in MapViewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (1000104..1002023, complement)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Akr1p Neighboring gene ubiquitin-protein ligase peroxin 10 Neighboring gene Cia1p Neighboring gene tryptophan--tRNA ligase MSW1

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
histone catabolic process IMP
Inferred from Mutant Phenotype
more info
 
histone ubiquitination IDA
Inferred from Direct Assay
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ribosome IDA
Inferred from Direct Assay
more info
PubMed 
Names
Hel2p
NP_010552.3
  • RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 

    Range
    1000104..1002023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180574.3NP_010552.3  Hel2p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_010552.3

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q05580
    Conserved Domains (1) summary
    cd00162
    Location:64106
    Blast Score: 87
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...