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    UPC2 Upc2p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851799, updated on 21-May-2012
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    Summary

    Gene symbol
    UPC2
    Gene description
    Upc2p
    Primary source
    SGD:S000002621
    Locus tag
    YDR213W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MOX4
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    Genomic context

    Location :
    chromosome: IV
    Sequence :
    Chromosome: IV; NC_001136.10 (889751..892492)
    See UPC2 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Gcd6p Neighboring gene Tcp1p Neighboring gene Aha1p Neighboring gene Adr1p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    2. Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Gilmore JM, et al. Mol Cell Proteomics, 2012 Apr. PMID 22199229.
    3. Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Rosenbaum JC, et al. Mol Cell, 2011 Jan 7. PMID 21211726.
    4. Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, et al. Science, 2010 Dec 3. PMID 21127252.
    5. Epistatic relationships reveal the functional organization of yeast transcription factors. Zheng J, et al. Mol Syst Biol, 2010 Oct 5. PMID 20959818.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Perinuclear localization of Upc2p-GFP and Ecm22p-GFP was increased when ergosterol biosynthesis was blocked by azole drug treatment.
      Title: Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae.
    2. Upc2p and Ecm22p differ in their contributions to the regulation of their targets
      Title: Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_010499.1 NP_012035.1 PRP8    BIND  PubMed Prp8 interacts with Upc2. 
    BioGRID:32267 BioGRID:33177 AFT1    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:32891 AIM4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36025 AIM44    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:34950 APQ12    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32226 ARG82    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36562 ARP1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32267 BioGRID:36905 BEM2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:31987 BRE1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35093 BUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:33817 CBF1    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:33405 CHO2    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33353 CLB6    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32204 CTH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35092 CTK3    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:36278 DBF20    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32105 DET1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:32701 ECM15    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:31498 ECM22    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect; Synthetic Rescue 
    BioGRID:32267 BioGRID:32094 ENA2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:35380 ERG2    BioGRID  PubMed Phenotypic Suppression; Synthetic Growth Defect; Synthetic Lethality 
    BioGRID:32267 BioGRID:36780 ERG28    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32267 BioGRID:35161 ERG6    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32267 BioGRID:34860 FKH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32682 FUS3    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:36491 FYV4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35117 GAL80    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35005 GAT4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35635 GCR2    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:32559 GIN4    BioGRID  PubMed Dosage Growth Defect 
    BioGRID:32267 BioGRID:31522 HAP1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32267 BioGRID:32665 HEK2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32267 BioGRID:32710 HHF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:35797 HHF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:35204 HOF1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:32775 HSP26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:33848 IME1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33650 IME2    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:30960 KCC4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32067 KCS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31800 KIN3    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31063 KIN82    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33287 KSS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35009 MET28    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33500 MGA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35245 MOT3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32267 BioGRID:34071 MSN4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32330 MTH1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:34213 NUP133    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:33102 NUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:34195 OAF3    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33303 PEF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31191 PHO4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:34403 PHO80    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:32492 PPZ2    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36599 PRP8    BioGRID  PubMed Two-hybrid 
    BioGRID:32267 BioGRID:32048 PTC1    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:36841 RAD51    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:31970 RAM1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:35725 RAS2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:31078 RDS1    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:32197 SAN1    BioGRID  PubMed Two-hybrid 
    BioGRID:32267 BioGRID:33167 SCY1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:33591 SET2    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:32807 SIF2    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:34400 SIN3    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32561 SMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32267 BioGRID:32529 SNF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:33938 SPE1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36137 SSN3    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:35801 SSN8    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:35530 STB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35229 STB2    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31632 SUR4    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32267 BioGRID:31033 THR4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32645 TOD6    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31454 TOS4    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:32827 TPS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35246 TVP18    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32267 BioGRID:32633 UBP13    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36319 URN1    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:31106 YFL040W    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:33299 YGR054W    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:36515 YHR080C    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:33600 YJL160C    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:34104 YKL027W    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32267 BioGRID:31546 YLR278C    BioGRID  PubMed Positive Genetic 
    BioGRID:32267 BioGRID:35889 YNR063W    BioGRID  PubMed Negative Genetic 
    BioGRID:32267 BioGRID:35142 YOX1    BioGRID  PubMed Negative Genetic 
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    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Names
    Upc2p
    NP_010499.1
    • Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      889751..892492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180521.1 → NP_010499.1  Upc2p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q12151
      Conserved Domains (2) summary
      cd00067
      Location:46 – 81
      Blast Score: 155
      GAL4; GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations
      pfam11951
      Location:612 – 753
      Blast Score: 157
      Fungal_trans_2; Fungal specific transcription factor domain
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA12057.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12151.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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