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HOM2 aspartate-semialdehyde dehydrogenase [ Saccharomyces cerevisiae S288c ]

Gene ID: 851736, updated on 23-Aug-2016
Gene symbol
HOM2
Gene description
aspartate-semialdehyde dehydrogenase
Primary source
SGD:S000002565
Locus tag
YDR158W
Gene type
protein coding
RNA name
aspartate-semialdehyde dehydrogenase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
THR2
See HOM2 in Map Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (770357..771454)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase CPR1 Neighboring gene DNA-directed RNA polymerase I subunit RPA14 Neighboring gene Sac3p Neighboring gene Ssy1p

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
N-acetyl-gamma-glutamyl-phosphate reductase activity IEA
Inferred from Electronic Annotation
more info
 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
aspartate-semialdehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
aspartate-semialdehyde dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aspartate metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
homoserine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
 
methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
methionine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
threonine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
threonine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Names
aspartate-semialdehyde dehydrogenase
NP_010442.3
  • Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    770357..771454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180465.3NP_010442.3  aspartate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_010442.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13663
    Conserved Domains (3) summary
    PRK08664
    Location:7365
    PRK08664; aspartate-semialdehyde dehydrogenase; Reviewed
    pfam01118
    Location:8130
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain
    pfam02774
    Location:165346
    Semialdhyde_dhC; Semialdehyde dehydrogenase, dimerization domain