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IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [ Homo sapiens (human) ]

Gene ID: 8517, updated on 24-Aug-2015
Official Symbol
IKBKGprovided by HGNC
Official Full Name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaprovided by HGNC
Primary source
HGNC:HGNC:5961
See related
Ensembl:ENSG00000269335; HPRD:02217; MIM:300248; Vega:OTTHUMG00000024234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; IMD33; AMCBX1; ZC2HC9; IKK-gamma
Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
Orthologs
See IKBKG in Epigenomics, MapViewer
Location:
Xq28
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (154541204..154568573)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153769419..153796804)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 10, member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene family with sequence similarity 223, member A (non-protein coding) Neighboring gene activating transcription factor 4 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 cytoplasmic domain-induced NFkappaB activation requires TAK1, RelA, and NEMO proteins PubMed

Go to the HIV-1, Human Interaction Database

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  • Pancreatic cancer, organism-specific biosystem (from KEGG)
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  • RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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  • RIP-mediated NFkB activation via ZBP1, organism-specific biosystem (from REACTOME)
    RIP-mediated NFkB activation via ZBP1, organism-specific biosystemOverexpression of human or murine ZBP1 (DAI) in human embryonic kidney 293T cells (HEK293T) activated NF-kB-dependent promoter in a dose-dependent manner. Two RHIM-contaning kinases RIP1 and RIP3 are...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
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  • Shigellosis, organism-specific biosystem (from KEGG)
    Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells
  • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD8+ T cells, organism-specific biosystem
    TCR signaling in naive CD8+ T cells
  • TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TNF receptor signaling pathway, organism-specific biosystem
    TNF receptor signaling pathway
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
  • TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated NF-kB activation, organism-specific biosystemThe TRAF6/TAK1 signal activates a canonical IKK complex, resulting in the activation of NF-kB as well as MAPK cascades leading to the activation of AP-1. Although TRAF6/TAK1 has been implicated in To...
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
  • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TRAIL signaling pathway, organism-specific biosystem
    TRAIL signaling pathway
  • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
    TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
  • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
  • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
  • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
    ZBP1(DAI) mediated induction of type I IFNs, organism-specific biosystemZ-DNA-binding protein-1 (ZBP1), also known as, DNA-dependent activator of IFN-regulatory factors (DAI) was reported to initiate innate immune responses in murine L929 cells upon stimulation by multip...
  • activated TAK1 mediates p38 MAPK activation, organism-specific biosystem (from REACTOME)
    activated TAK1 mediates p38 MAPK activation, organism-specific biosystemp38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stre...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
K63-linked polyubiquitin binding IEA
Inferred from Electronic Annotation
more info
 
linear polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
activation of NF-kappaB-inducing kinase activity IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
establishment of vesicle localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neuron death TAS
Traceable Author Statement
more info
PubMed 
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
response to virus TAS
Traceable Author Statement
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 3 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 4 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR1:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor TLR6:TLR2 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
IkappaB kinase complex TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with IkappaB kinase complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase subunit gamma
IKKAP1
IKKG
IkB kinase gamma subunit
NF-kappa-B essential modifier
NFkappaB essential modulator
ikB kinase subunit gamma
ikB kinase-associated protein 1
incontinentia pigmenti
inhibitor of nuclear factor kappa-B kinase subunit gamma

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009896.1 RefSeqGene

    Range
    5001..27803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_70

mRNA and Protein(s)

  1. NM_001099856.3NP_001093326.2  NF-kappa-B essential modulator isoform b

    See identical proteins and their annotated locations for NP_001093326.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and initiates translation from an alternate in-frame upstream start codon compared to variant 1. The resulting isoform (b) has a longer N-terminus compared to isoform a.
    Source sequence(s)
    AF062089, AY114157, BC000299
    Consensus CDS
    CCDS48196.1
    UniProtKB/Swiss-Prot
    Q9Y6K9
    Related
    ENSP00000483825, OTTHUMP00000276767, ENST00000618670, OTTHUMT00000061154
    Conserved Domains (2) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:326412
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  2. NM_001099857.2NP_001093327.1  NF-kappa-B essential modulator isoform a

    See identical proteins and their annotated locations for NP_001093327.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AF062089, AK308366, BC000299, BC050612
    Consensus CDS
    CCDS14757.1
    UniProtKB/Swiss-Prot
    Q9Y6K9
    Related
    ENSP00000471166, OTTHUMP00000276782, ENST00000594239, OTTHUMT00000061156
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:258344
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  3. NM_001145255.2NP_001138727.1  NF-kappa-B essential modulator isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons in the central coding region compared to variant 1. The resulting isoform (c) lacks two internal protein segments compared to isoform a.
    Source sequence(s)
    AF062089, AK000593, AK308366, BC000299
    Consensus CDS
    CCDS48197.1
    UniProtKB/Swiss-Prot
    Q9Y6K9
    Related
    ENSP00000478616, OTTHUMP00000276786, ENST00000611176, OTTHUMT00000061158
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:203245
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  4. NM_003639.4NP_003630.1  NF-kappa-B essential modulator isoform a

    See identical proteins and their annotated locations for NP_003630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AF062089, AF261086, BC000299
    Consensus CDS
    CCDS14757.1
    UniProtKB/Swiss-Prot
    Q9Y6K9
    Related
    ENSP00000479662, OTTHUMP00000276788, ENST00000611071, OTTHUMT00000061157
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:258344
    UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    154541204..154568573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531204.1XP_011529506.1  

    See identical proteins and their annotated locations for XP_011529506.1

    UniProtKB/Swiss-Prot
    Q9Y6K9
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:258344
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  2. XM_011531205.1XP_011529507.1  

    See identical proteins and their annotated locations for XP_011529507.1

    UniProtKB/Swiss-Prot
    Q9Y6K9
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:258344
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  3. XM_011531206.1XP_011529508.1  

    Conserved Domains (1) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
  4. XM_011531207.1XP_011529509.1  

    Conserved Domains (1) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
  5. XM_005274761.3XP_005274818.1  

    Conserved Domains (2) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:326412
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  6. XM_011531203.1XP_011529505.1  

    Conserved Domains (3) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:275361
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam03938
    Location:187325
    OmpH; Outer membrane protein (OmpH-like)
  7. XM_005274760.3XP_005274817.1  

    Conserved Domains (2) summary
    pfam11577
    Location:112179
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:325411
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  8. XM_005274764.3XP_005274821.1  

    UniProtKB/TrEMBL
    A0A087X1B1
    Related
    ENSP00000484023, OTTHUMP00000276785, ENST00000617207, OTTHUMT00000348893
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:257343
    UBAN; polyubiquitin binding domain of NEMO and related proteins

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    153682228..153705030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)