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    DPB4 Dpb4p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851699, updated on 12-May-2012
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    Summary

    Gene symbol
    DPB4
    Gene description
    Dpb4p
    Primary source
    SGD:S000002528
    Locus tag
    YDR121W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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    Genomic context

    Location :
    chromosome: IV
    Sequence :
    Chromosome: IV; NC_001136.10 (693585..694175)
    See DPB4 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Trm1p Neighboring gene Kin1p Neighboring gene Ino2p

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Disparity in the DNA translocase domains of SWI/SNF and ISW2. Dechassa ML, et al. Nucleic Acids Res, 2012 May 1. PMID 22298509.
    2. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Sharifpoor S, et al. Genome Res, 2012 Apr. PMID 22282571.
    3. Development of a multiplexed microfluidic proteomic reactor and its application for studying protein-protein interactions. Tian R, et al. Anal Chem, 2011 Jun 1. PMID 21520965.
    4. Sensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase ε. Puddu F, et al. PLoS Genet, 2011 Mar. PMID 21436894.
    5. Polymerase epsilon is required to maintain replicative senescence. Deshpande AM, et al. Mol Cell Biol, 2011 Apr. PMID 21321081.

    See all (41) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_010406.1 NP_015501.2 DPB2    BIND  PubMed Dpb2p interacts with Dpb4p. 
    NP_010406.1 NP_009837.1 DPB3    BIND  PubMed Dpb3p interacts with Dpb4p. 
    BioGRID:32177 BioGRID:36025 AIM44    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36693 ANP1    BioGRID  PubMed Positive Genetic 
    BioGRID:32177 BioGRID:33684 ARG2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:31358 ARP6    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34535 ARP8    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:31040 BUD31    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35041 CAC2    BioGRID  PubMed Positive Genetic 
    BioGRID:32177 BioGRID:31825 CDC13    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32177 BioGRID:31376 CDC45    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32177 BioGRID:33814 CDC8    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35376 CIK1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36288 CLB5    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:32207 CPR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35835 CSE2    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36302 CTF4    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36625 CTF8    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35989 DDC1    BioGRID  PubMed Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:31753 DEP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34479 DIA2    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:33689 DLS1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:32177 BioGRID:33667 DPB11    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32177 BioGRID:36348 DPB2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:32972 DPB3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Synthetic Rescue; Two-hybrid 
    BioGRID:32177 BioGRID:32177 DPB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:31961 DUN1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:32415 EAF1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32177 BioGRID:34635 ESA1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32177 BioGRID:32559 GIN4    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36776 GLN3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32177 BioGRID:32388 GPI8    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:32347 HDA2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32177 BioGRID:34440 HIR2    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34428 HST3    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:32700 HTB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:34392 HTZ1    BioGRID  PubMed Affinity Capture-MS; Negative Genetic; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:31133 IES1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:35621 IES2    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:31327 IES3    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36837 IES5    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:31691 IMD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:34692 ISW2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Phenotypic Enhancement; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:33119 ITC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:32177 BioGRID:36516 LRP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:33632 LSM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35681 LSM7    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32177 BioGRID:31742 LTE1    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32177 BioGRID:36242 MED1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34632 MET7    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32177 BioGRID:36014 MEX67    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32177 BioGRID:33830 MOG1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36099 MOT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:30926 MRC1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:35077 MSC1    BioGRID  PubMed Positive Genetic 
    BioGRID:32177 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:32177 BioGRID:32052 NHP10    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34213 NUP133    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:31599 NUP2    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:33102 NUT1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35101 ORC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:36918 PAB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:31052 PAT1    BioGRID  PubMed Negative Genetic; Synthetic Growth Defect 
    BioGRID:32177 BioGRID:35577 POL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Dosage Rescue; Phenotypic Enhancement; Synthetic Lethality; Two-hybrid 
    BioGRID:32177 BioGRID:31960 POL3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:31292 POM34    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34021 RAD27    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32177 BioGRID:36030 RAD53    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:32177 BioGRID:32270 RAD9    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:35725 RAS2    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36016 REV3    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32177 BioGRID:31793 RFA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:34612 RFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:31447 RFX1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32177 BioGRID:36195 RLF2    BioGRID  PubMed Synthetic Rescue 
    BioGRID:32177 BioGRID:36813 RNR1    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32177 BioGRID:32629 RPS8A    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:36462 RRM3    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:32177 BioGRID:32646 SAS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:34908 SDS3    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:31352 SIC1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:32177 BioGRID:36861 SLX8    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:33153 SRM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34865 STH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:32177 BioGRID:35567 TOF1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35539 TRF5    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35141 TSA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:32658 URA7    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:32177 BioGRID:33348 VMA21    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:35717 YAF9    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:34063 YKL069W    BioGRID  PubMed Negative Genetic 
    BioGRID:32177 BioGRID:33519 YTA7    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
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    General gene information

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to DNA-directed DNA polymerase activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lagging strand elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    lagging strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lagging strand elongation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    leading strand elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    leading strand elongation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromatin accessibility complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    epsilon DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Names
    Dpb4p
    NP_010406.1
    • Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      693585..694175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180429.1 → NP_010406.1  Dpb4p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q04603
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA11967.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04603.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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