STN1 Stn1p [Saccharomyces cerevisiae S288c] - Gene

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Summary

Gene symbol: STN1
Gene description: Stn1p
Primary source: SGD:S000002489
Locus tag: YDR082W
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288c (strain: S288c)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

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Genomic context

Sequence :: Chromosome: IV; NC_001136.10 (610441..611925)

See STN1 in MapViewer

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the crystal structures of the C-terminal domain of the Saccharomyces cerevisiae Stn1 and the Schizosaccharomyces pombe Ten1 proteins are reported.
Title: Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Stn1 overrides DNA replication control through the S phase checkpoint
Title: Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint.
The N terminus of Stn1 interacts with Ten1 and carries out its essential capping function. The C terminus of Stn1 binds both Cdc13 and Pol12.
Title: Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition.
identified distinct Stn1p domains that mediate interaction with either Ten1p or Cdc13p, allowing analysis of whether the interaction between Cdc13p and Stn1p is indeed essential for telomere capping or length regulation
Title: The role of Stn1p in Saccharomyces cerevisiae telomere capping can be separated from its interaction with Cdc13p.
Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates.
Title: RPA-like proteins mediate yeast telomere function.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_010367.1	NP_010061.1	CDC13	BIND	PubMed	Cdc13 interacts with Stn1.
NP_010367.1	NP_013110.1	TEN1	BIND	PubMed	Stn1 interacts with Ten1.
BioGRID:32138	BioGRID:31825	CDC13	BioGRID	PubMed	Affinity Capture-Western; Dosage Lethality; Dosage Rescue; Phenotypic Enhancement; Phenotypic Suppression; Synthetic Lethality; Two-hybrid
BioGRID:32138	BioGRID:31058	CSM1	BioGRID	PubMed	Two-hybrid
BioGRID:32138	BioGRID:31582	EST2	BioGRID	PubMed	Dosage Rescue; Phenotypic Enhancement; Synthetic Growth Defect; Synthetic Lethality
BioGRID:32138	BioGRID:35473	HER2	BioGRID	PubMed	Negative Genetic
BioGRID:32138	BioGRID:35364	HSC82	BioGRID	PubMed	Dosage Rescue
BioGRID:32138	BioGRID:36857	LSM4	BioGRID	PubMed	Two-hybrid
BioGRID:32138	BioGRID:35721	POL1	BioGRID	PubMed	Dosage Rescue
BioGRID:32138	BioGRID:32662	POL12	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Synthetic Lethality; Synthetic Rescue; Two-hybrid
BioGRID:32138	BioGRID:36926	RAD24	BioGRID	PubMed	Synthetic Lethality
BioGRID:32138	BioGRID:35589	RAD50	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:32138	BioGRID:35137	RAD52	BioGRID	PubMed	Phenotypic Enhancement; Synthetic Lethality
BioGRID:32138	BioGRID:32270	RAD9	BioGRID	PubMed	Synthetic Growth Defect; Synthetic Lethality
BioGRID:32138	BioGRID:32970	RIF1	BioGRID	PubMed	Synthetic Lethality
BioGRID:32138	BioGRID:31419	STM1	BioGRID	PubMed	Dosage Rescue
BioGRID:32138	BioGRID:32616	TEL1	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:32138	BioGRID:31283	TEN1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Dosage Rescue; Phenotypic Suppression; Reconstituted Complex; Synthetic Rescue; Two-hybrid
BioGRID:32138	BioGRID:36026	TGS1	BioGRID	PubMed	Phenotypic Enhancement

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General gene information

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
single-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
negative regulation of telomere maintenance via telomerase	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
telomere capping	IGI Inferred from Genetic Interaction more info	PubMed
telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
telomere capping	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
chromosome	IEA Inferred from Electronic Annotation more info
chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
nuclear telomere cap complex	IPI Inferred from Physical Interaction more info	PubMed

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General protein information

Names: Stn1p

NP_010367.1

Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10

Range

610441..611925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180390.1 → NP_010367.1 Stn1p [Saccharomyces cerevisiae S288c]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P38960

Conserved Domains (2) summary

pfam12659
Location:362 – 491
Blast Score: 372

Stn1_C; Telomere capping C-terminal wHTH

cl09930
Location:4 – 290
Blast Score: 797

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.