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LCB2 serine C-palmitoyltransferase LCB2 [ Saccharomyces cerevisiae S288c ]

Gene ID: 851634, updated on 3-Jul-2016
Gene symbol
LCB2
Gene description
serine C-palmitoyltransferase LCB2
Primary source
SGD:S000002469
Locus tag
YDR062W
Gene type
protein coding
RNA name
serine C-palmitoyltransferase LCB2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SCS1; TSC1
See LCB2 in Map Viewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (576474..578159)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene RNA-binding ribosome biosynthesis protein MAK21 Neighboring gene hypothetical protein Neighboring gene Aim7p Neighboring gene ribosomal 40S subunit protein S13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
serine C-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
serine C-palmitoyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
serine C-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SPOTS complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
serine C-palmitoyltransferase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Names
serine C-palmitoyltransferase LCB2
NP_010347.1
  • Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    576474..578159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180370.1NP_010347.1  serine C-palmitoyltransferase LCB2 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_010347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40970
    Conserved Domains (2) summary
    cd06454
    Location:156519
    KBL_like; KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), ...
    COG0156
    Location:104519
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]