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    PSF1 Psf1p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851576, updated on 9-May-2013
    Gene symbol
    PSF1
    Gene description
    Psf1p
    Primary source
    SGD:S000002420
    Locus tag
    YDR013W
    Gene type
    protein coding
    RNA name
    Psf1p
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CDC101
    Location :
    chromosome: IV
    Sequence :
    Chromosome: IV; NC_001136.10 (473157..473783)
    See PSF1 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette transporter SNQ2 Neighboring gene ribosomal 60S subunit protein L4B Neighboring gene Rad61p Neighboring gene Hed1p

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. Sengupta S, et al. Curr Biol, 2013 Apr 8. PMID 23499531.
    2. Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. van Pel DM, et al. G3 (Bethesda), 2013 Feb. PMID 23390603.
    3. Functional analysis with a barcoder yeast gene overexpression system. Douglas AC, et al. G3 (Bethesda), 2012 Oct. PMID 23050238.
    4. A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome. Kilkenny ML, et al. J Biol Chem, 2012 Jul 6. PMID 22593576.
    5. Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. van Deursen F, et al. EMBO J, 2012 May 2. PMID 22433841.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. GINS (Psf1, Psf2, Psf3, and Sld5) and Sld3 compete with one another for Mcm2-7 and Cdc45 binding
      Title: GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding.
    Submit: New GeneRIF Correction
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:32064 BioGRID:33807 BFA1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33440 BUB1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:34429 BUB3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:31376 CDC45    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32064 BioGRID:31676 CDC73    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:32969 CHK1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36169 CHL1    BioGRID  PubMed Negative Genetic; Synthetic Lethality 
    BioGRID:32064 BioGRID:33227 CKB1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36288 CLB5    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35434 COX7    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35835 CSE2    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:31058 CSM1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35222 CSM3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35254 CTF18    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36302 CTF4    BioGRID  PubMed Co-purification; Negative Genetic; Reconstituted Complex; Synthetic Lethality; Two-hybrid 
    BioGRID:32064 BioGRID:36625 CTF8    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:30968 DCC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35989 DDC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33667 DPB11    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue; Two-hybrid 
    BioGRID:32064 BioGRID:36348 DPB2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:32064 BioGRID:32972 DPB3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:31961 DUN1    BioGRID  PubMed Dosage Lethality 
    BioGRID:32064 BioGRID:35479 DYN3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:32691 HIR1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34440 HIR2    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33896 HIR3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33895 HOM6    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:32912 HPC2    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:32775 HSP26    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34428 HST3    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33164 MAD1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33729 MAD2    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34842 MCM10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:32675 MCM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:32064 BioGRID:36697 MCM3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32064 BioGRID:36196 MCM4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:32064 BioGRID:31542 MCM5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32064 BioGRID:33056 MCM6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32064 BioGRID:32899 MCM7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:32064 BioGRID:30926 MRC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35402 MRE11    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:35959 NEW1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36551 ORC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:33344 PCP1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35741 PMS1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35721 POL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:32662 POL12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:35577 POL2    BioGRID  PubMed Dosage Rescue 
    BioGRID:32064 BioGRID:32794 POL30    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:33794 POL32    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33683 PSF2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:32064 BioGRID:34271 PSF3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Reconstituted Complex 
    BioGRID:32064 BioGRID:35379 RAD14    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34751 RAD17    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36926 RAD24    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:36841 RAD51    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:32270 RAD9    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:31793 RFA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:32064 BioGRID:36282 RGC1    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33610 RPA34    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34858 RPL16A    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:35368 SGS1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:34025 SLD2    BioGRID  PubMed Affinity Capture-Western; Dosage Rescue 
    BioGRID:32064 BioGRID:33138 SLD3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:32064 BioGRID:32541 SLD5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Dosage Rescue; Two-hybrid 
    BioGRID:32064 BioGRID:33524 TAF1    BioGRID  PubMed Synthetic Lethality 
    BioGRID:32064 BioGRID:34385 TLG2    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:31214 VPS13    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33260 YGR017W    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:33808 YJR054W    BioGRID  PubMed Negative Genetic 
    BioGRID:32064 BioGRID:34182 YKR051W    BioGRID  PubMed Negative Genetic 

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA-dependent DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    DNA replication preinitiation complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    DNA replication preinitiation complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    GINS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    replication fork protection complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Names
    Psf1p
    NP_010296.3
    • Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      473157..473783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180321.3 → NP_010296.3  Psf1p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q12488
      Conserved Domains (1) summary
      cd11710
      Location:3 – 143
      Blast Score: 301
      GINS_A_psf1; Alpha-helical domain of GINS complex protein Psf1
    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA11859.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12488.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • Taxonomy
        Link to related taxonomy entry

      Links to other resources

      General information

      Related sites

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