PTC1 type 2C protein phosphatase PTC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: PTC1
Gene description: type 2C protein phosphatase PTC1
Primary source: SGD:S000002164
Locus tag: YDL006W
See related: AllianceGenome:SGD:S000002164
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CWH47; KCS2; TPD1
Summary: Enables MAP kinase serine/threonine phosphatase activity. Involved in several processes, including mitochondrion inheritance; peptidyl-threonine dephosphorylation; and pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (439909..440754)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Ptc1 is required for proper G2-M cell cycle transition after activation of the cell wall integrity pathway.
Title: The Saccharomyces cerevisiae Ptc1 protein phosphatase attenuates G2-M cell cycle blockage caused by activation of the cell wall integrity pathway.
biochemical and genetic evidence that Mkk1 transmits most of the signaling through the CWI pathway and that Ptc1 directly downregulates the CWI pathway at the level of the MAPKKs
Title: Wide-Ranging Effects of the Yeast Ptc1 Protein Phosphatase Acting Through the MAPK Kinase Mkk1.
Ptc1 has overlapping functions with Reg1-Glc7 and Sit4 in glucose regulation of SNF1/AMPK and cell viability.
Title: Ptc1 protein phosphatase 2C contributes to glucose regulation of SNF1/AMP-activated protein kinase (AMPK) in Saccharomyces cerevisiae.
Ptc1p regulates Mmr1p phosphorylation, localization, and function.
Title: Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast.
Nbp2 serves as the network hub and brings seven kinases in close contact to Ptc1.
Title: A constraint network of interactions: protein-protein interaction analysis of the yeast type II phosphatase Ptc1p and its adaptor protein Nbp2p.
PTC1 promotes the association of myosin-V with its organelle-specific adaptor proteins.
Title: PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex.
Results show that Ptc1, a type 2C protein phosphatase, is required for the normal functioning of the TOR pathway.
Title: Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1.
Expression profiling of the 6 protein phosphatase 2C family and the effects of mutation of the Ptc1 gene on gene expression and phenotype are reported
Title: Transcriptional profiling of the protein phosphatase 2C family in yeast provides insights into the unique functional roles of Ptc1.
These findings indicate that Ptc1p and Nbp2p regulate endoplasmic reticulum inheritance through the cell wall integrity (CWI) mitogen-activated protein kinase (MAPK) pathway by modulating the MAPK, Slt2p.
Title: Ptc1p regulates cortical ER inheritance via Slt2p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables cation binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fungal-type cell wall organization or biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: type 2C protein phosphatase PTC1

NP_010278.3

EC 3.1.3.16

Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating the osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; involved in myosin-V dependent inheritance of mitochondria, peroxisomes, vacuoles and secretory vesicles; localizes to the nucleus, cytoplasm and peroxisomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

439909..440754

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180065.3 → NP_010278.3 TPA: type 2C protein phosphatase PTC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010278.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRY2, P35182

UniProtKB/TrEMBL

A0A6A5Q151, A6ZXW0, B3LGR4, C7GXZ6, C8Z4R4, G2WCE8, N1PAB2

Conserved Domains (1) summary

smart00332
Location:12 → 279

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain