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LYS21 homocitrate synthase LYS21 [ Saccharomyces cerevisiae S288c ]

Gene ID: 851425, updated on 27-Jun-2015
Gene symbol
LYS21
Gene description
homocitrate synthase LYS21
Primary source
SGD:S000002289
Locus tag
YDL131W
Gene type
protein coding
RNA name
homocitrate synthase LYS21
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See LYS21 in MapViewer
Location:
chromosome: IV
Exon count:
1
Sequence:
Chromosome: IV; NC_001136.10 (227393..228715)

Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Srf1p Neighboring gene cullin CDC53 Neighboring gene Stf1p Neighboring gene ribosomal protein P1B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GO

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
homocitrate synthase activity IEA
Inferred from Electronic Annotation
more info
 
homocitrate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process via aminoadipic acid IGI
Inferred from Genetic Interaction
more info
PubMed 
lysine biosynthetic process via aminoadipic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
homocitrate synthase LYS21
NP_010151.1
  • Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001136.10 Reference assembly

    Range
    227393..228715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180190.1NP_010151.1  homocitrate synthase LYS21 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_010151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q12122
    Conserved Domains (2) summary
    TIGR02146
    Location:39385
    Putative_homocitrate_synthase; homocitrate synthase
    cd07948
    Location:37298
    DRE_TIM_HCS; Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain