My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    RPN5 Rpn5p [ Saccharomyces cerevisiae S288c ]

    Gene ID: 851408, updated on 4-Feb-2012
    Help top of page

    Summary

    Gene symbol
    RPN5
    Gene description
    Rpn5p
    Primary source
    SGD:S000002306
    Locus tag
    YDL147W
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NAS5
    Help top of page

    Genomic context

    Sequence :
    Chromosome: IV; NC_001136.10 (190924..192261)
    See RPN5 in MapViewer

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atg9p Neighboring gene Nop14p Neighboring gene Ldb17p Neighboring gene Cop1p

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Novel interactions between actin and the proteasome revealed by complex haploinsufficiency. Haarer B, et al. PLoS Genet, 2011 Sep. PMID 21966278.
    2. The catalytic activity of Ubp6 enhances maturation of the proteasomal regulatory particle. Sakata E, et al. Mol Cell, 2011 Jun 10. PMID 21658604.
    3. Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. Gomez TA, et al. BMC Biol, 2011 May 31. PMID 21627799.
    4. Not4 E3 ligase contributes to proteasome assembly and functional integrity in part through Ecm29. Panasenko OO, et al. Mol Cell Biol, 2011 Apr. PMID 21321079.
    5. Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome. Yu Z, et al. Mol Biol Cell, 2011 Apr. PMID 21289098.

    See all (43) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data demonstrate that, in Saccharomyces cerevisiae, Rpn5 plays dual roles by stabilizing 26S proteasome and COP9 signalosome structures independently.
      Title: Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.
    Submit: New GeneRIF Correction
    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:31914 BioGRID:31107 ACT1    BioGRID  PubMed Synthetic Haploinsufficiency 
    BioGRID:31914 BioGRID:32914 ATG12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31140 BLM10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31015 BPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33513 BUD32    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31937 CDC48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35197 CSI1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:31914 BioGRID:32232 CSN9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:31914 BioGRID:33335 DBF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32124 DOA4    BioGRID  PubMed Two-hybrid 
    BioGRID:31914 BioGRID:36392 ECM29    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33058 EMP24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31785 ERV46    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32418 ESC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31747 FUN30    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35584 GIS2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31914 BioGRID:32967 HSM3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:31003 HTL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33111 HUL5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35921 IQG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35474 JNM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33845 JSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:31914 BioGRID:34866 KGD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36331 KRE6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36857 LSM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34249 MDH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33129 NAB2    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:31914 BioGRID:34985 NAS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33484 NAS6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:32018 NAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36604 NMD3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34604 NPT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34658 PAC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36737 PAC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34921 PCI8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:30992 POL4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36744 PRE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:31914 BioGRID:34747 PRE10    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:36269 PRE2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33756 PRE3    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:31208 PRE4    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:35494 PRE5    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:34364 PRE6    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:32656 PRE7    BioGRID  PubMed Affinity Capture-MS; Positive Genetic 
    BioGRID:31914 BioGRID:35051 PRE8    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:33383 PRE9    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:32108 PST1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34553 PUP1    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:33504 PUP2    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:36840 PUP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35137 RAD52    BioGRID  PubMed Synthetic Growth Defect 
    BioGRID:31914 BioGRID:36458 RPN1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:31914 BioGRID:36634 RPN10    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:31152 RPN11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; PCA; Positive Genetic; Reconstituted Complex; Two-hybrid 
    BioGRID:31914 BioGRID:31210 RPN12    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:31680 RPN13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33241 RPN14    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:34917 RPN2    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:31914 BioGRID:36755 RPN3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:31914 RPN5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31965 RPN6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Two-hybrid 
    BioGRID:31914 BioGRID:36274 RPN7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:34651 RPN8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; PCA; Two-hybrid 
    BioGRID:31914 BioGRID:32485 RPN9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; PCA; Two-hybrid 
    BioGRID:31914 BioGRID:32505 RPS18A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33991 RPT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32047 RPT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32456 RPT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34649 RPT4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34513 RPT5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Positive Genetic 
    BioGRID:31914 BioGRID:33200 RPT6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31829 RRI1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:34283 RRI2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33235 SCL1    BioGRID  PubMed Affinity Capture-MS; Negative Genetic 
    BioGRID:31914 BioGRID:33676 SCP160    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32782 SEC18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32420 SEM1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:31914 BioGRID:36152 SKS1    BioGRID  PubMed Two-hybrid 
    BioGRID:31914 BioGRID:32041 SLX5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32128 SNF11    BioGRID  PubMed Two-hybrid 
    BioGRID:31914 BioGRID:32252 SPC19    BioGRID  PubMed Two-hybrid 
    BioGRID:31914 BioGRID:35369 SPG5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:35004 SQT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32376 SWA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31789 TFC3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36217 TIP41    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32645 TOD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32166 TRS85    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31215 UBI4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36901 UBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31160 UBP6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:32873 UMP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:31214 VPS13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:33839 YJR084W    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:31914 BioGRID:36180 YPR003C    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Homology

    • Homologs of the RPN5 gene: The RPN5 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, and rice.

    Pathways from BioSystems

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    cullin deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    proteasome complex IDA
    Inferred from Direct Assay
    more info
    		  
    proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signalosome IDA
    Inferred from Direct Assay
    more info
    		  
    Help top of page

    General protein information

    Names
    Rpn5p
    NP_010134.1
    • Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p
    Help top of page

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10

      Range
      190924..192261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180207.1 → NP_010134.1  Rpn5p [Saccharomyces cerevisiae S288c]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q12250
      Conserved Domains (1) summary
      cl02111
      Location:5 – 445
      Blast Score: 1532
      PCI; PCI domain
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BK006938.2 DAA11711.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q12250.3 GenPept
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...