SEC31 Sec31p [Saccharomyces cerevisiae S288c] - Gene

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Summary

Gene symbol: SEC31
Gene description: Sec31p
Primary source: SGD:S000002354
Locus tag: YDL195W
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288c (strain: S288c)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: WEB1

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Genomic context

Sequence :: Chromosome: IV; NC_001136.10 (107208..111029)

See SEC31 in MapViewer

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:31850	BioGRID:36025	AIM44	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:34988	BET1	BioGRID	PubMed	Co-fractionation; Reconstituted Complex
BioGRID:31850	BioGRID:32241	CCT6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34955	CKA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34460	CKA2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:33227	CKB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34640	CLP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:36907	COG3	BioGRID	PubMed	Synthetic Lethality
BioGRID:31850	BioGRID:31688	CRN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34084	CSE4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:35713	DBP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:36392	ECM29	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:33058	EMP24	BioGRID	PubMed	Reconstituted Complex
BioGRID:31850	BioGRID:35157	ERV25	BioGRID	PubMed	Reconstituted Complex
BioGRID:31850	BioGRID:34600	GEP3	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:32665	HEK2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:31850	BioGRID:35473	HER2	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:36651	IMD2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:36513	IRE1	BioGRID	PubMed	Dosage Rescue
BioGRID:31850	BioGRID:33726	KAR2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:32394	MRPS28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:33129	NAB2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:31850	BioGRID:35588	NRD1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:31850	BioGRID:31946	NUP84	BioGRID	PubMed	Co-purification
BioGRID:31850	BioGRID:34002	OCT1	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:35445	PPA2	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:31349	RPL10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:31979	RPL13A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34281	RPL18A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34248	RPL25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:31986	RPL31A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34627	RPL33B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:35913	RPL36B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34225	RPL40B	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:36220	RPL43A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:35068	RPL6A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:33174	RPL7A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:36458	RPN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:36634	RPN10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:32443	RPP2B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:32505	RPS18A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34923	RPS24B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:33953	SAC1	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:31476	SEC13	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:31850	BioGRID:36096	SEC16	BioGRID	PubMed	Affinity Capture-Western; Dosage Lethality; Reconstituted Complex; Two-hybrid
BioGRID:31850	BioGRID:31536	SEC22	BioGRID	PubMed	Co-fractionation
BioGRID:31850	BioGRID:36353	SEC23	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Dosage Lethality
BioGRID:31850	BioGRID:34882	SEC24	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:31850	BioGRID:36531	SFB3	BioGRID	PubMed	Synthetic Lethality
BioGRID:31850	BioGRID:31833	SHR3	BioGRID	PubMed	Affinity Capture-Western; Dosage Rescue; Synthetic Growth Defect
BioGRID:31850	BioGRID:31419	STM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:31215	UBI4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:31850	BioGRID:34016	VPH2	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:34133	VPS1	BioGRID	PubMed	Positive Genetic
BioGRID:31850	BioGRID:35636	WHI3	BioGRID	PubMed	Protein-RNA
BioGRID:31850	BioGRID:33424	YIP1	BioGRID	PubMed	Synthetic Lethality

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General gene information

Homology

Homologs of the SEC31 gene: The SEC31 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, and N.crassa.

Pathways from BioSystems

Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
Asparagine N-linked glycosylation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
COPII complex, organism-specific biosystem (from KEGG)
COPII complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
ER to Golgi Transport, organism-specific biosystem (from REACTOME)
ER to Golgi Transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
Transport to the Golgi and subsequent modification, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
COPII-coated vesicle budding	IDA Inferred from Direct Assay more info	PubMed
COPII-coated vesicle budding	IMP Inferred from Mutant Phenotype more info	PubMed
protein transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info
vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
COPII vesicle coat	IDA Inferred from Direct Assay more info	PubMed
ER to Golgi transport vesicle membrane	IEA Inferred from Electronic Annotation more info
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
mating projection tip	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info

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General protein information

Names: Sec31p

NP_010086.2

Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10

Range

107208..111029

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180255.2 → NP_010086.2 Sec31p [Saccharomyces cerevisiae S288c]

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P38968

Conserved Domains (3) summary

pfam11549
Location:905 – 947
Blast Score: 195

Sec31; Protein transport protein SEC31

PHA03247
Location:772 – 1126
Blast Score: 174

PHA03247; large tegument protein UL36; Provisional

cl02567
Location:17 – 327
Blast Score: 262

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...