U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

YAR009C truncated gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 851268, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Gene symbol
YAR009C
Gene description
truncated gag-pol fusion protein
Primary source
SGD:S000000067
Locus tag
YAR009C
See related
AllianceGenome:SGD:S000000067
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable several functions, including DNA polymerase activity; peptidase activity; and ribonuclease activity. Predicted to be involved in transposition, RNA-mediated. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: I
Exon count:
1
Sequence:
Chromosome: I; NC_001133.9 (160597..164187, complement)

Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene replication factor A subunit protein RFA1 Neighboring gene tRNA splicing endonuclease subunit SEN34 Neighboring gene gag protein Neighboring gene tRNA-Ala

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Post-transcriptional cosuppression of Ty1 retrotransposition. Garfinkel DJ, et al. Genetics, 2003 Sep. PMID 14504219, Free PMC Article
  2. Kinetic pathway of pyrophosphorolysis by a retrotransposon reverse transcriptase. Pandey M, et al. PLoS One, 2008 Jan 2. PMID 18167548, Free PMC Article
  3. A Ty1 reverse transcriptase active-site aspartate mutation blocks transposition but not polymerization. Uzun O, et al. J Virol, 2001 Jul. PMID 11413300, Free PMC Article
  4. A Ty1 integrase nuclear localization signal required for retrotransposition. Moore SP, et al. Mol Cell Biol, 1998 Feb. PMID 9448008, Free PMC Article
  5. Invading the yeast nucleus: a nuclear localization signal at the C terminus of Ty1 integrase is required for transposition in vivo. Kenna MA, et al. Mol Cell Biol, 1998 Feb. PMID 9448009, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA nuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retrotransposition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transposition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in retrotransposon nucleocapsid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
truncated gag-pol fusion protein
NP_009406.1
  • Retrotransposon TYA Gag and TYB Pol genes; Gag processing produces capsid proteins, Pol is cleaved to produce protease, reverse transcriptase and integrase activities; in YARCTy1-1 TYB is mutant and probably non-functional; protein product forms cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001133.9 Reference assembly

    Range
    160597..164187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178213.1 → NP_009406.1  TPA: truncated gag-pol fusion protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_009406.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VPM1, O13527
    UniProtKB/TrEMBL
    A0A8H4C1G7
    Conserved Domains (3) summary
    cd09272
    Location:1047 → 1183
    RNase_HI_RT_Ty1; Ty1/Copia family of RNase HI in long-term repeat retroelements
    pfam00665
    Location:105 → 223
    rve; Integrase core domain
    pfam07727
    Location:722 → 921
    RVT_2; Reverse transcriptase (RNA-dependent DNA polymerase)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13527.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous